Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study
Gopal S, Ajgaonkar A, Kanchi P, Kaundinya A, Thakare V, Chauhan S, Langade D
The journal of obstetrics and gynaecology research · 36 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-09-22 · J Obstet Gynaecol Res · vol. 47 · número 12 · págs. 4414–4425
- Editorial
- Wiley
- Citado
- 52 citas · más que el 93% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Menopause: Health Impacts and Treatments · Estrogen and related hormone effects
- Palabras clave
- Climacteric, Medicine, Placebo, Menopause, Withania somnifera, Testosterone (patch), Tolerability, Hormone, Internal medicine, Luteinizing hormone, Randomized controlled trial, Physiology, Black cohosh, Endocrinology, Adverse effect
- MeSH
- humans, withania, hot flashes, plant extracts, double-blind method, perimenopause, quality of life, female
7 autores
- Sriram Gopal🇮🇳D.Y. Patil University
- Ashutosh Ajgaonkar🇮🇳Bhaktivedanta Hospital & Research Institute
- Padmaja Kanchi🇮🇳Terna Dental College and Hospital
- Aditi Kaundinya🇮🇳D.Y. Patil University
- Vaishali Thakare🇮🇳 · autor de correspondenciaD.Y. Patil University
- Sanjaya Chauhan🇮🇳Narayana Health
- Deepak Langade🇮🇳D.Y. Patil University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Perimenopause is the period during which many physiological changes mark the transition into the final menstrual period of a woman and these changes are associated with climacteric symptoms.
Objectives
This study aimed to assess the efficacy and tolerability of an Ashwagandha root extract on the climacteric symptoms, quality of life (QoL), and hormonal parameters in perimenopausal women.
Materials and methods
In this 8-week, randomized, double-blind, placebo-controlled study, 100 women with climacteric symptoms were randomly allocated to take either a placebo or 300 mg of an Ashwagandha root extract twice daily. Outcomes were measured using the menopause rating scale (MRS), menopause-specific QoL (MENQoL), hot flash score, and hormonal changes in estradiol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone.
Results
Among 100 participants enrolled, 91 participants completed the study. In comparison with the placebo, ashwagandha supplementation was associated with a statistically significant reduction in total MRS score (p < 0.0001), reflected by significant reductions in the psychological (p = 0.0003), somato-vegetative (p = 0.0152), and urogenital (p < 0.0001) domains. Ashwagandha intake demonstrated a statistically significant reduction in total MENQoL scores (p < 0.0001) and was also associated with a statistically significant increase in serum estradiol (p < 0.0001) and a significant reduction in serum FSH (p < 0.0001) and serum LH (p < 0.05) compared with the placebo. There was no significant between the group differences in the serum testosterone level.
Conclusion
These findings suggest that ashwagandha root extract can be a safe and effective option to relieve mild to moderate climacteric symptoms during perimenopause in women.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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