Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis
Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R
PloS one · 47 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universiti Sains Malaysia
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-09-24 · PLoS One · vol. 16 · número 9 · pág. e0257843
- Editorial
- Public Library of Science
- Citado
- 86 citas · más que el 96% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Banking Sector Performance and Management · Medicinal Plant Extracts Effects
- Palabras clave
- Medicine, Withania somnifera, Insomnia, Randomized controlled trial, Placebo, Anxiety, Meta-analysis, Alertness, Adverse effect, Confidence interval, Traditional medicine, Strictly standardized mean difference, Quality of life (healthcare), Physical therapy, Internal medicine, Psychiatry, Alternative medicine
- MeSH
- humans, sleep initiation and maintenance disorders, plant extracts, drug administration schedule, anxiety, sleep, quality of life, randomized controlled trials as topic
4 autores
- Kae Ling Cheah🇲🇾 · autor de correspondenciaHospital Universiti Sains Malaysia
- Mohd Noor Norhayati🇲🇾 · autor de correspondenciaHospital Universiti Sains Malaysia
- Lili Husniati Yaacob🇲🇾 · autor de correspondenciaHospital Universiti Sains Malaysia
- Razlina Abdul Rahman🇲🇾 · autor de correspondenciaHospital Universiti Sains Malaysia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine the effect of Ashwagandha extract on sleep.
Methods
A comprehensive search was conducted in CENTRAL, MEDLINE, SCOPUS, Google Scholars, World Health Organization Trials Portal, ClinicalTrials.gov, Clinical Trial Registry of India, and AYUSH Research Portal for all appropriate trials. Randomized controlled trials that examined the effect of Ashwagandha extract versus placebo on sleep in human participants 18 years old and above were considered. Two authors independently read all trials and independently extracted all relevant data. The primary outcomes were sleep quantity and sleep quality. The secondary outcomes were mental alertness on rising, anxiety level, and quality of life.
Results
A total of five randomized controlled trials containing 400 participants were analyzed. Ashwagandha extract exhibited a small but significant effect on overall sleep (Standardized Mean Difference -0.59; 95% Confidence Interval -0.75 to -0.42; I2 = 62%). The effects on sleep were more prominent in the subgroup of adults diagnosed with insomnia, treatment dosage ≥600 mg/day, and treatment duration ≥8 weeks. Ashwagandha extract was also found to improve mental alertness on rising and anxiety level, but no significant effect on quality of life. No serious side effects were reported.
Conclusion
Ashwagandha extract appears to has a beneficial effect in improving sleep in adults. However, data on the serious adverse effects of Ashwagandha extract are limited, and more safety data would be needed to assess whether it would be safe for long-term use.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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