Time-restricted feeding improves blood glucose and insulin sensitivity in overweight patients with type 2 diabetes: a randomised controlled trial
Che T, Yan C, Tian D, Zhang X, Liu X, Wu Z
Nutrition & metabolism · 149 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Innovative Research Group Project of the National Natural Science Foundation of China
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Tianjin City
- Gobierno
- Natural Science Foundation of Tianjin Municipal Science and Technology Commission
- Gobierno
- Natural Science Foundation of Tianjin-Science and Technology Correspondent Project
- Subvenciones
- Natural Science Foundation of Tianjin City (19JCZDJC36900); Natural Science Foundation of Tianjin Municipal Science and Technology Commission (RC20165); National Natural Science Foundation of China (81671835); National Natural Science Foundation of China (ZC20143); Natural Science Foundation of Tianjin Municipal Science and Technology Commission (19JCZDJC36900); Innovative Research Group Project of the National Natural Science Foundation of China (81671835); Natural Science Foundation of Tianjin-Science and Technology Correspondent Project (ZC20143)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-10-07 · Nutr Metab (Lond) · vol. 18 · número 1 · pág. 88
- Editorial
- BioMed Central
- Citado
- 211 citas · más que el 99% de estudios similares · 13.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Enhanced Recovery After Surgery · Genetics, Aging, and Longevity in Model Organisms
- Palabras clave
- Overweight, Medicine, Internal medicine, Type 2 diabetes, Clinical nutrition, Diabetes mellitus, Insulin resistance, Insulin, Endocrinology, Obesity, Randomized controlled trial, Gastroenterology
6 autores
- Tingting Che🇨🇳Tianjin Medical University
- Yan Cheng🇨🇳Tianjin Medical University
- Ding‐Yuan Tian🇨🇳Tianjin Medical University
- Xin Zhang🇨🇳Tianjin Medical University
- Xuejun Liu🇨🇳 · autor de correspondenciaTianjin Medical University
- Zhongming Wu🇨🇳 · autor de correspondenciaSecond Hospital of Tianjin Medical University; Tianjin Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Time-restricted feeding is an emerging dietary intervention that is becoming increasingly popular. There are, however, no randomised clinical trials of time-restricted feeding in overweight patients with type 2 diabetes. Here, we explored the effects of time-restricted feeding on glycaemic regulation and weight changes in overweight patients with type 2 diabetes over 12 weeks.
Methods
Overweight adults with type 2 diabetes (n = 120) were randomised 1:1 to two diet groups: time-restricted feeding (n = 60) or control (n = 60). Sixty patients participated in a 10-h restricted feeding treatment program (ad libitum feeding from 8:00 to 18:00 h; fasting between 18:00 and 8:00 h) for 12 weeks.
Results
Haemoglobin A1c and body weight decreased in the time-restricted feeding group (- 1.54% ± 0.19 and - 2.98 ± 0.43 kg, respectively) relative to the control group over 12 weeks (p < 0.001). Homeostatic model assessment of β-cell function and insulin resistance changed in the time-restricted feeding group (0.73 ± 0.21, p = 0.005; - 0.51 ± 0.08, p = 0.02, respectively) compared with the control group. The medication effect score, SF-12 score, and the levels of triglycerides, total cholesterol and low-density lipoprotein cholesterol were improved in the time-restricted feeding group (- 0.66 ± 0.17, p = 0.006; 5.92 ± 1.38, p < 0.001; - 0.23 ± 0.08 mmol/L, p = 0.03; - 0.32 ± 0.07 mmol/L, p = 0.01; - 0.42 ± 0.13 mmol/L, p = 0.02, respectively) relative to the control group. High-density lipoprotein cholesterol was not significantly different between the two groups.
Conclusion
These results suggest that 10-h restricted feeding improves blood glucose and insulin sensitivity, results in weight loss, reduces the necessary dosage of hypoglycaemic drugs and enhances quality of life. It can also offer cardiovascular benefits by reducing atherosclerotic lipid levels.
Trial registration
This study was registered with the Chinese Clinical Trial Registry (ChiCTR-IPR-15006371).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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