Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors
Moro T, Tinsley G, Pacelli FQ, Marcolin G, Bianco A, Paoli A
Medicine and science in sports and exercise · 115 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-07-09 · Med Sci Sports Exerc · vol. 53 · número 12 · págs. 2577–2585
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 133 citas · más que el 99% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Genetics, Aging, and Longevity in Model Organisms · Enhanced Recovery After Surgery
- Palabras clave
- Medicine, Insulin resistance, Internal medicine, Calorie, Lipid profile, Body mass index, Endocrinology, Homeostatic model assessment, Adverse effect, Insulin, Cholesterol
- MeSH
- humans, insulin resistance, insulin-like growth factor i, body mass index, fasting, single-blind method, energy intake, male, adiposity, resistance training, cardiometabolic risk factors
6 autores
- Tatiana Rojo Moro🇮🇹University of Padua
- Grant M. Tinsley🇺🇸Texas Tech University
- F Pacelli🇮🇹University of Padua
- Giuseppe Marcolin🇮🇹University of Padua
- Antonino Bianco🇮🇹University of Palermo
- Antonio Paoli🇮🇹University of Padua
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Recently, a modified intermittent fasting protocol was demonstrated to be able to maintain muscle mass and strength, decrease fat mass, and improve some inflammation and cardiovascular risk factors in healthy resistance-trained males after 2 months. The present study sought to investigate the long-term effects on these parameters.
Methods
The experiment was a single-blind randomized study. Twenty healthy subjects were enrolled and underwent 12 months of either a time-restricted eating (TRE) diet or a normal diet (ND) protocol, along with resistance training. In the TRE protocol, subjects consumed their energy needs in three meals during an 8-h period of time each day (1 pm, 4 pm, and 8 pm). Subjects in the ND group also had three meals, which were consumed at 8 am, 1 pm, and 8 pm. Groups were matched for kilocalories consumed and macronutrient distribution at baseline.
Results
After 12 months of TRE, body mass, fat mass, insulin-like growth factor 1, and testosterone were significantly lower compared with ND. Moreover, inflammatory markers (interleukin 6, interleukin 1β, and tumor necrosis factor α), insulin sensitivity (fasting glucose, insulin, and homeostatic model assessment for insulin resistance index), and lipid profile (cholesterol, HDL, and LDL) significantly improved after TRE compared with ND. Finally, subjects in TRE spontaneously decreased their daily energy intake, whereas those in ND maintained their starting kilocalories per day. No adverse events were reported.
Conclusions
Our results suggest that long-term TRE combined with a resistance training program is feasible, safe, and effective in reducing inflammatory markers and risk factors related to cardiovascular and metabolic diseases.
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