Effects of photobiomodulation and a physical exercise program on the expression of inflammatory and cartilage degradation biomarkers and functional capacity in women with knee osteoarthritis: a randomized blinded study
Vassão PG, de Souza ACF, da Silveira Campos RM, Garcia LA, Tucci HT, Renno ACM
Advances in rheumatology (London, England) · 20 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2016/08503-0)
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-10-16 · Adv Rheumatol · vol. 61 · número 1 · pág. 62
- Editorial
- Elsevier BV
- Citado
- 28 citas · más que el 92% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Osteoarthritis Treatment and Mechanisms · Laser Applications in Dentistry and Medicine · Musculoskeletal pain and rehabilitation
- Palabras clave
- knee osteoarthritis, low-level laser therapy, physical activity, functional capacity, inflammatory markers, cartilage degradation biomarkers, IL-10, IL-1β, CTX-II, women
- MeSH
- humans, osteoarthritis, knee, interleukin-10, treatment outcome, exercise therapy, female, biomarkers, low-level light therapy, physical functional performance
6 autores
- Patrícia Gabrielli Vassão🇧🇷 · autor de correspondenciaUniversidade Federal de São Paulo
- Ana Carolina Flygare Souza🇧🇷Universidade Federal de São Paulo
- Raquel Munhoz da Silveira Campos🇧🇷Universidade Federal de São Paulo
- Livia Assis Garcia🇧🇷Universidade Brasil
- Helga Tatiana Tucci🇧🇷Universidade Federal de São Paulo
- Ana Cláudia Muniz Rennó🇧🇷Universidade Federal de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The knee osteoarthritis (OA) is a joint disease characterized by degradation of articular cartilage that leads to chronic inflammation. Exercise programs and photobiomodulation (PBM) are capable of modulating the inflammatory process of minimizing functional disability related to knee OA. However, their association on the concentration of biomarkers related to OA development has not been studied yet. The aim of the present study is to investigate the effects of PBM (via cluster) with a physical exercise program in functional capacity, serum inflammatory and cartilage degradation biomarkers in patients with knee OA.
Methods
Forty-two patients were randomly allocated in 3 groups: ESP: exercise + sham PBM; EAP: exercise + PBM and CG: control group. Six patients were excluded before finished the experimental period. The analyzed outcomes in baseline and 8-week were: the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and the evaluation of serum biomarkers concentration (IL-1β, IL-6, IL-8, IL-10 e TNF-α, and CTX-II).
Results
An increase in the functional capacity was observed in the WOMAC total score for both treated groups (p < 0.001) and ESP presents a lower value compared to CG (p < 0.05) the 8-week post-treatment. In addition, there was a significant increase in IL-10 concentration of EAP (p < 0.05) and higher value compared to CG (p < 0.001) the 8-week post-treatment. Moreover, an increase in IL-1β concentration was observed for CG (p < 0.05). No other difference was observed comparing the other groups.
Conclusion
Our data suggest that the physical exercise therapy could be a strategy for increasing functional capacity and in association with PBM for increasing IL-10 levels in OA knee individuals.
Trial registration
ReBEC (RBR-7t6nzr).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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