IgE Antibodies to Galactose-α-1,3-galactose, an Epitope of Red Meat Allergen, Cross-react With a Novel Flounder Roe Allergen

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Publicado

2021-10-15 · J Investig Allergol Clin Immunol · vol. 32 · número 4 · págs. 324–326

Editorial

ESMON Publicidad

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8 citas · más que el 61% de estudios similares · 0.5× el promedio de su campo

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Acceso

Acceso abierto (publicación gratuita)

Áreas de investigación

Food Allergy and Anaphylaxis Research · Mast cells and histamine · Identification and Quantification in Food

Palabras clave

Medicine, Allergen, Epitope, Immunology, Immunoglobulin E, Antibody, Galactose, Allergy, Microbiology, Biology, Biochemistry

MeSH

animals, flounder, humans, food hypersensitivity, galactose, disaccharides, immunoglobulin e, allergens, epitopes, meat, red meat

3 autores

• Yuko Chinuki🇯🇵Shimane University
• Hitoshi Takahashi🇯🇵Hiroshima University
• Eishin Morita🇯🇵Shimane University

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Methods SubjectsThirty patients with red meat allergy (19 men and 11 women; age range: 37-88 years; average age: 69.2 ± 8.4 years), enrolled in the study, were referred to the Department of Dermatology at the Shimane University Hospital (Shimane, Japan).The diagnosis of red meat allergy was made following an episode of allergic symptoms after ingestion of red meat and positive serum IgE tests for beef and -Gal (ImmunoCAP Ⓡ , Thermo Fischer Diagnostics, Tokyo, Japan).Some of these cases have previously been described as beef allergy [6], and the clinical features of these patients are summarized in Supplementary Table 1.After ingestion of red meat, urticaria was the predominant allergic symptom observed in 29 of the 30 patients, whereas 7 of the 30 patients developed anaphylactic shock.More than 60% of the documented 35 allergy episodes of these 30 patients appeared 3 h after ingestion of red meat or later, and 23% of the episodes developed in over 5 h.Twenty of the 30 patients showed allergic reactions after ingesting flounder with roe that had been fished from the Sea of Japan during winter season.All of these 20 patients had generalized urticaria, and seven of them developed anaphylactic shock a few hours after a meal as with red meat allergy.The episodes of flounder roe allergy followed the episodes with red meat allergy in most of the patients, and the patients had no allergic symptoms after ingesting flounder without roe.Five healthy subjects who had no allergy against either red meat or flounder roe were enrolled as negative controls. Allergen-specific IgE tests and skin prick testsAllergen-specific IgE antibodies were measured using CAP-fluorescent enzyme immunoassay (ImmunoCAP Ⓡ ) for beef (f27), flounder meat (f254), and -Gal (o215).Skin prick tests were performed on the volar surface of the arm.Histamine solution (10 mg/mL) was used as positive control, and saline as negative control.Fresh flounder fish Hippoglossoides dubius with roe were procured from a local supermarket on each day of testing, and prick-to-prick tests were performed with heated and non-

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