Effects of magnesium supplementation on post-thyroidectomy hypocalcemia: a prospective single-center study
Minuto MN, Santori G, Ansaldo GL, Solari N, Boschetti M, Tassone C, Barbieri S, Reina S, Mascherini M, Varaldo E
Minerva endocrinology · 1 cita
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Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-10-20 · Minerva Endocrinol (Torino) · vol. 49 · número 2 · págs. 132–140
- Editorial
- Edizioni Minerva Medica
- Citado
- 3 citas · más que el 68% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thyroid and Parathyroid Surgery · Parathyroid Disorders and Treatments · Magnesium in Health and Disease
- Palabras clave
- Medicine, Hypomagnesemia, Contraindication, Hypoparathyroidism, Thyroidectomy, Surgery, Prospective cohort study, Parathyroid hormone, Magnesium, Single Center, Thyroid, Gastroenterology, Calcium, Internal medicine
- MeSH
- humans, hypocalcemia, hypoparathyroidism, postoperative complications, calcium, magnesium, thyroidectomy, prospective studies, dietary supplements, adult, aged, middle aged, female, male
10 autores
- Michele N Minuto🇺🇸🇮🇹 · autor de correspondenciaMartin University; Ospedale Policlinico San Martino; University of Genoa
- Gregorio Santori🇮🇹University of Genoa
- Gian Luca Ansaldo🇺🇸🇮🇹Martin University; Ospedale Policlinico San Martino
- Nicola Solari🇺🇸🇮🇹Martin University; Ospedale Policlinico San Martino
- Mara Boschetti🇺🇸🇮🇹Martin University; Ospedale Policlinico San Martino; University of Genoa
- Caterina Tassone🇺🇸🇮🇹Martin University; Ospedale Policlinico San Martino
- Stefano Barbieri🇺🇸🇮🇹Martin University; Ospedale Policlinico San Martino; University of Genoa
- Simona Reina🇺🇸🇮🇹Martin University; Ospedale Policlinico San Martino
- Matteo Mascherini🇺🇸🇮🇹Martin University; Ospedale Policlinico San Martino
- Emanuela Varaldo🇺🇸🇮🇹Martin University; Ospedale Policlinico San Martino; University of Genoa
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Severe and/or symptomatic hypocalcemia due to hypoparathyroidism is the main contraindication for discharge in patients who have undergone thyroid surgery. Hypomagnesemia may contribute to the onset of hypoparathyroidism and is frequently observed after thyroid surgery in hypocalcemic patients. The impact of prophylactic and postoperative Magnesium supplementation on postoperative hypocalcemia and hypomagnesemia was prospectively evaluated by comparing patients undergoing prophylactic supplementation to a control group of patients who had only received magnesium after evidence of postoperative hypomagnesemia.
Methods
One hundred and twenty patients who underwent a total thyroidectomy participated in the study. Seventy-three patients were included in the study group, 47 in the control group. Prior to surgery, patients in the study group were given magnesium orally for 5 days; postoperatively, calcium and magnesium was administered to all patients who displayed hypocalcemia and hypomagnesemia.
Results
Postoperative biochemical hypocalcemia (serum calcium <8.5 mg/dL, regardless of its clinical severity) was found in 60 patients (50%) on D1 and in 58 patients (48.4%) on D2. Among hypocalcemic patients, hypomagnesemia was recorded in 29 at D1 (48%), and in 46 at D2 (79%). A significant positive correlation was found between magnesium, calcium, and parathyroid hormone in the first two postoperative days, while a significant inverse correlation occurred for these same parameters and length of hospital stay (P<0.001). One hundred and five patients (87.5%) were discharged as expected on the second postoperative day (65 in the study group, 40 in the control group, P=0.724), whereas 15 patients (12.5%) required prolonged hospitalization (eight in the study group, seven in the control group, P=0.721). The Study group only showed significantly higher magnesium levels on the first postoperative day (P=0.03).
Conclusions
Although magnesium and calcium levels showed the same trend after thyroidectomy, neither Magnesium prophylaxis nor Magnesium treatment influenced the clinical course of postoperative hypocalcemia.
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