On the implication of dietary nitrate supplementation for the hemodynamic and fatigue response to cycling exercise
Thurston TS, Weavil JC, Hureau TJ, Gifford JR, Georgescu VP, Wan HY, La Salle DT, Richardson RS, Amann M
Journal of applied physiology (Bethesda, Md. : 1985) · 15 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Rehabilitation Research and Development Service
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- Veterans Affairs (VA) Rehabilitation Research and Development Service
- Gobierno
- NHLBI NIH HHS
- Gobierno
- HHS | NIH | National Heart, Lung, and Blood Institute
- Subvenciones
- National Heart, Lung, and Blood Institute (T32 HL 139451); National Heart, Lung, and Blood Institute (HL103786); National Heart, Lung, and Blood Institute (HL457 116579); National Heart, Lung, and Blood Institute (HL139451); Rehabilitation Research and Development Service (E6910‐R); Rehabilitation Research and Development Service (E1572‐P); Rehabilitation Research and Development Service (E3207‐R); Rehabilitation Research and Development Service (E1697-R); National Heart, Lung, and Blood Institute (R00 HL103786); National Heart, Lung, and Blood Institute (K99 HL103786)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2021-10-21 · J Appl Physiol (1985) · vol. 131 · número 6 · págs. 1691–1700
- Editorial
- American Physiological Society
- Citado
- 16 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control · Sports Performance and Training
- Palabras clave
- Hemodynamics, Cycling, Haemodynamic response, Blood pressure, Muscle fatigue, Cardiology, Internal medicine, Blood flow, Nitrate, Medicine, Heart failure, Dietary Nitrate, Physical medicine and rehabilitation, Physical therapy, Heart rate, Chemistry, Electromyography
- MeSH
- muscle, skeletal, humans, beta vulgaris, nitrates, exercise, cross-over studies, double-blind method, muscle fatigue, dietary supplements, male, hemodynamics
9 autores
- Taylor S. Thurston🇺🇸University of Utah
- Joshua C. Weavil🇺🇸Geriatric Research Education and Clinical Center
- Thomas J. Hureau🇺🇸University of Utah
- Jayson R. Gifford🇺🇸University of Utah
- Vincent P. Georgescu🇺🇸University of Utah
- Hsuan‐Yu Wan🇺🇸University of Utah
- David Taylor La Salle🇺🇸University of Utah
- Russell S. Richardson🇺🇸University of Utah; Geriatric Research Education and Clinical Center
- Markus Amann🇺🇸 · autor de correspondenciaUniversity of Utah; Geriatric Research Education and Clinical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study investigated the impact of dietary nitrate supplementation on peripheral hemodynamics, the development of neuromuscular fatigue, and time to task failure during cycling exercise. Eleven recreationally active male participants (27 ± 5 yr, V̇o2max: 42 ± 2 mL/kg/min) performed two experimental trials following 3 days of either dietary nitrate-rich beetroot juice (4.1 mmol NO3-/day; DNS) or placebo (PLA) supplementation in a blinded, counterbalanced order. Exercise consisted of constant-load cycling at 50, 75, and 100 W (4 min each) and, at ∼80% of peak power output (218 ± 12 W), to task-failure. All participants returned to repeat the shorter of the two trials performed to task failure, but with the opposite supplementation regime (iso-time comparison; ISO). Mean arterial pressure (MAP), leg blood flow (QL; Doppler ultrasound), leg vascular conductance (LVC), and pulmonary gas exchange were continuously assessed during exercise. Locomotor muscle fatigue was determined by the change in pre to postexercise quadriceps twitch-torque (ΔQtw) and voluntary activation (ΔVA; electrical femoral nerve stimulation). Following DNS, plasma [nitrite] (∼670 vs. ∼180 nmol) and [nitrate] (∼775 vs. ∼11 μmol) were significantly elevated compared with PLA. Unlike PLA, DNS lowered both QL and MAP by ∼8% (P P = 0.31). V̇O2 across work rates, as well as cycling time to task-failure (∼7 min) and locomotor muscle fatigue following the ISO-time comparison were not different between the two conditions (ΔQtw ∼42%, ΔVA ∼4%). Thus, despite significant hemodynamic changes, DNS did not alter the development of locomotor muscle fatigue and, ultimately, cycling time to task failure.NEW & NOTEWORTHY This study sought to characterize the impact of dietary nitrate supplementation on the hemodynamic response, locomotor muscle fatigue, and time to task failure during cycling exercise. Although nitrate supplementation lowered mean arterial pressure and exercising leg blood flow, leg vascular conductance and oxygen utilization were unaffected. Despite significant hemodynamic changes, there was no effect of dietary nitrate on neuromuscular fatigue development and, ultimately, cycling time to task failure.
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