The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies
Bellerba F, Muzio V, Gnagnarella P, Facciotti F, Chiocca S, Bossi P, Cortinovis D, Chiaradonna F, Serrano D, Raimondi S, Zerbato B, Palorini R, Canova S, Gaeta A, Gandini S
Nutrients · 91 citas
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Università degli Studi di Brescia
- Gobierno
- Grant Regione Lombardia. (DECRETO N. 7082 Del 17/06/2020. Identificativo Atto n. 366: COVi-taminD Trial: prevenzione di complicanze da COVID-19 in pazienti oncologici).
- Universidad u hospital
- Federica Bellerba is a Ph.D. student within the European School of Molecular Medicine (SEMM).
- Gobierno
- The European Institute of Oncology, Milan, Italy is partially supported by the Italian Ministry of Health with Ricerca Corrente and 5×1,000 funds
Según 4 financiadores declarados.
Publicación
- Publicado
- 2021-09-26 · Nutrients · vol. 13 · número 10 · pág. 3378
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 123 citas · más que el 82% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gut microbiota and health · Vitamin D Research Studies · Probiotics and Fermented Foods
- Palabras clave
- vitamin D, gut microbiota, vitamin D supplementation, vitamin D intake, 25-hydroxyvitamin D, Firmicutes, actinobacteria, Bacteroidetes, microbial diversity, Veillonellaceae, Oscillospiraceae, microbiota composition
- MeSH
- humans, vitamins, vitamin d, dietary supplements, gastrointestinal microbiome
15 autores
- Federica Bellerba🇮🇹European Institute of Oncology
- Valeria Muzio🇮🇹European Institute of Oncology
- Patrizia Gnagnarella🇮🇹 · autor de correspondenciaEuropean Institute of Oncology
- Federica Facciotti🇮🇹European Institute of Oncology
- Susanna Chiocca🇮🇹European Institute of Oncology
- Paolo Bossi🇮🇹Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia; University of Brescia
- Diego Luigi Cortinovis🇮🇹Azienda Ospedaliera San Gerardo
- Ferdinando Chiaradonna🇮🇹University of Milano-Bicocca
- Davide Serrano🇮🇹European Institute of Oncology
- Sara Raimondi🇮🇹European Institute of Oncology
- Barbara Zerbato🇮🇹University of Milano-Bicocca
- Roberta Palorini🇮🇹University of Milano-Bicocca
- Stefania Canova🇮🇹Azienda Ospedaliera San Gerardo
- Aurora Gaeta🇮🇹European Institute of Oncology
- Sara Gandini🇮🇹European Institute of Oncology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Recent evidence has shown a number of extra-skeletal functions of Vitamin D (VD), primarily involving the immune system. One of these functions is mediated by the modulation of gut microbiota, whose alterations are linked to many diseases. Our purpose is to contribute to the understanding of existing evidence on the association between VD and gastrointestinal microbiota alterations. A systematic review of studies with human subjects has been conducted up to January 2021. We included publications reporting the association between gut microbiota and VD, including VD supplementation, dietary VD intake and/or level of 25(OH)D. We identified 25 studies: 14 were interventional and 11, observational. VD supplementation was found to be associated with a significant change in microbiome composition, in particular of Firmicutes, Actinobacteria and Bacteroidetes phyla. Furthermore, Firmicutes were found to be correlated with serum VD. Concerning alpha and beta diversity, a high nutritional intake of VD seems to induce a shift in bacterial composition and/or affects the species' richness. Veillonellaceae and Oscillospiraceae families, in the Firmicutes phylum, more frequently decreased with both increasing levels of 25(OH)D and vitamin D supplementation. We found evidence of an association, even though the studies are substantially heterogeneous and have some limitations, resulting sometimes in conflicting results. To further understand the role of VD on the modulation of the gastrointestinal microbiota, future research should be geared toward well-designed animal-based studies or larger randomized controlled trials (RCTs).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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