Low linoleic acid foods with added DHA given to Malawian children with severe acute malnutrition improve cognition: a randomized, triple-blinded, controlled clinical trial
Stephenson K, Callaghan-Gillespie M, Maleta K, Nkhoma M, George M, Park HG, Lee R, Humphries-Cuff I, Lacombe RJS, Wegner DR, Canfield RL, Brenna JT, Manary MJ
The American journal of clinical nutrition · 22 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Children's Discovery Institute
- Universidad u hospital
- Children's Discovery Institute
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-10-28 · Am J Clin Nutr · vol. 115 · número 5 · págs. 1322–1333
- Editorial
- Elsevier BV
- Citado
- 34 citas · más que el 89% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Child Nutrition and Water Access · Fatty Acid Research and Health · Infant Nutrition and Health
- Palabras clave
- severe acute malnutrition, ready-to-use therapeutic food, DHA supplementation, high-oleic peanut, polyunsaturated fatty acids, children's cognition, neurocognitive recovery, plasma fatty acids, problem-solving skills, Malawi, eye tracking, alpha-linolenic acid
- MeSH
- humans, malnutrition, prostate-specific antigen, linoleic acid, cognition, child, infant, male, fast foods, severe acute malnutrition
13 autores
- Kevin B. Stephenson🇺🇸Washington University in St. Louis
- Meghan Callaghan‐Gillespie🇺🇸Washington University in St. Louis
- Kenneth Mphatso Maleta🇲🇼Kamuzu University of Health Sciences
- Minyanga Nkhoma🇲🇼Kamuzu University of Health Sciences
- Matthews George🇲🇼Kamuzu University of Health Sciences
- Hui Gyu Park🇺🇸The University of Texas at Austin
- Reginald S. Lee🇺🇸Washington University in St. Louis
- Iona Humphries-Cuff
- R. J. Scott Lacombe🇺🇸The University of Texas at Austin
- Donna R. Wegner🇺🇸Washington University in St. Louis
- Richard L. Canfield🇺🇸The University of Texas at Austin
- James Thomas Brenna🇺🇸Cornell University; The University of Texas at Austin
- MARK J. MANARY🇺🇸🇲🇼 · autor de correspondenciaAgricultural Research Service; United States Department of Agriculture; Washington University in St. Louis; Kamuzu University of Health Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There is concern that the PUFA composition of ready-to-use therapeutic food (RUTF) for the treatment of severe acute malnutrition (SAM) is suboptimal for neurocognitive recovery.
Objectives
We tested the hypothesis that RUTF made with reduced amounts of linoleic acid, achieved using high-oleic (HO) peanuts without added DHA (HO-RUTF) or with added DHA (DHA-HO-RUTF), improves cognition when compared with standard RUTF (S-RUTF).
Methods
A triple-blind, randomized, controlled clinical feeding trial was conducted among children with uncomplicated SAM in Malawi with 3 types of RUTF: DHA-HO-RUTF, HO-RUTF, and S-RUTF. The primary outcomes, measured in a subset of subjects, were the Malawi Developmental Assessment Tool (MDAT) global z-score and a modified Willatts problem-solving assessment (PSA) intention score for 3 standardized problems, measured 6 mo and immediately after completing RUTF therapy, respectively. MDAT domain z-scores, plasma fatty acid content, anthropometry, and eye tracking were secondary outcomes. Comparisons were made between the novel PUFA RUTFs and S-RUTF.
Results
Among the 2565 SAM children enrolled, mean global MDAT z-scores were -0.69 ± 1.19 and -0.88 ± 1.27 for children receiving DHA-HO-RUTF and S-RUTF, respectively (difference 0.19, 95% CI: 0.01, 0.38). Children receiving DHA-HO-RUTF had higher gross motor and social domain z-scores than those receiving S-RUTF. The PSA problem 3 scores did not differ by dietary group (OR: 0.92, 95% CI: 0.67, 1.26 for DHA-HO-RUTF). After 4 wk of treatment, plasma phospholipid EPA and α-linolenic acid were greater in children consuming DHA-HO-RUTF or HO-RUTF when compared with S-RUTF (for all 4 comparisons P values < 0.001), but only plasma DHA was greater in DHA-HO-RUTF than S-RUTF (P < 0.001).
Conclusions
Treatment of uncomplicated SAM with DHA-HO-RUTF resulted in an improved MDAT score, conferring a cognitive benefit 6 mo after completing diet therapy. This treatment should be explored in operational settings. This trial was registered at clinicaltrials.gov as NCT03094247.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.