Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality
Liu X, Yang W, Petrick JL, Liao LM, Wang W, He N, Campbell PT, Zhang ZF, Giovannucci E, McGlynn KA, Zhang X
Nature communications · 75 citas
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Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Organización sin fines de lucro
- American Cancer Society
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- U.S. Department of State
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- Pennsylvania Department of Health
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- Florida Department of Health
- Universidad u hospital
- Emory University
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- Arizona Department of Health Services
- Universidad u hospital
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- Harvard T.H. Chan School of Public Health
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- Missouri Department of Health and Senior Services
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- National Institutes of Health
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- National Cancer Institute
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- the Intramural Research Program of Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Subvenciones
- American Cancer Society (NEC-130476); National Cancer Institute (K07 CA188126); Division of Cancer Epidemiology and Genetics, National Cancer Institute (K07 CA188126); National Cancer Institute (CA188126); National Institutes of Health (R21 CA238651); National Institutes of Health (CA188126); National Institutes of Health (K07CA188126); National Cancer Institute (R21 CA238651)
Según 17 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-11-04 · Nat Commun · vol. 12 · número 1 · pág. 6388
- Editorial
- Nature Portfolio
- Citado
- 98 citas · más que el 99% de estudios similares · 9.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Nutritional Studies and Diet · Food Security and Health in Diverse Populations
- Palabras clave
- Medicine, Liver cancer, Hazard ratio, Internal medicine, Chronic liver disease, Whole grains, Cancer, Liver disease, Refined grains, Proportional hazards model, Disease, Confidence interval, Cohort, Cohort study, Gastroenterology, Cirrhosis, Biology, Food science
- MeSH
- humans, liver neoplasms, liver diseases, proportional hazards models, eating, dietary fiber, aged, middle aged, female, male, surveys and questionnaires, edible grain
11 autores
- Xing Liu🇺🇸🇨🇳Harvard University; Fudan University
- Wanshui Yang🇺🇸🇨🇳Brigham and Women's Hospital; Harvard University; Anhui Medical University
- Jessica L. Petrick🇺🇸Boston University
- Linda M. Liao🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Weibing Wang🇨🇳Fudan University
- Na He🇨🇳Fudan University
- Peter T. Campbell🇺🇸American Cancer Society
- Zuo‐Feng Zhang🇺🇸University of California, Los Angeles; UCLA Jonsson Comprehensive Cancer Center
- Edward L. Giovannucci🇺🇸Brigham and Women's Hospital; Harvard University
- Katherine A. McGlynn🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Xuehong Zhang🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The relationship between dietary factors and liver disease remains poorly understood. This study evaluated the associations of whole grain and dietary fiber intake with liver cancer risk and chronic liver disease mortality. The National Institutes of Health-American Association of Retired Persons Diet and Health Study cohort recruited 485, 717 retired U.S. participants in 1995-1996. Follow-up through 2011 identified 940 incident liver cancer cases and 993 deaths from chronic liver disease. Compared with the lowest, the highest quintile of whole grain intake was associated with lower liver cancer risk (Hazard ratio [HR]Q5 vs. Q1 = 0.78, 95% confidence interval [CI]: 0.63-0.96) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.44, 95% CI: 0.35-0.55) in multivariable Cox models. Dietary fiber was also associated with lower liver cancer risk (HRQ5 vs. Q1 = 0.69, 95% CI: 0.53-0.90) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.37, 95% CI: 0.29-0.48). Fiber from vegetables, beans and grains showed potential protective effect. Here, we show that higher intake of whole grain and dietary fiber are associated with lower risk of liver cancer and liver disease mortality.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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