Oral Magnesium Supplementation for the Prevention of Preeclampsia: a Meta-analysis or Randomized Controlled Trials
Yuan J, Yu Y, Zhu T, Lin X, Jing X, Zhang J
Biological trace element research · 15 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-11-13 · Biol Trace Elem Res · vol. 200 · número 8 · págs. 3572–3581
- Editorial
- Springer Science+Business Media
- Citado
- 22 citas · más que el 70% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Pregnancy and preeclampsia studies · Magnesium in Health and Disease · Maternal and fetal healthcare
- Palabras clave
- Medicine, Preeclampsia, Relative risk, Meta-analysis, Subgroup analysis, Randomized controlled trial, Confidence interval, Cochrane Library, Pregnancy, Internal medicine, Incidence (geometry), Obstetrics
- MeSH
- humans, pre-eclampsia, magnesium, pregnancy, dietary supplements, female, randomized controlled trials as topic
6 autores
- Jing Yuan🇨🇳117th Hospital of People's Liberation Army
- Ying Yu🇨🇳Zhangqiu City People's Hospital
- Tongyu Zhu · autor de correspondencia
- Xiaohan Lin
- Xincheng Jing
- Juan Zhang
Resumen
El texto original del estudio, en el idioma en que se publicó.
Previous studies evaluating the role of magnesium supplementation as a preventative strategy for preeclampsia showed inconsistent results. We performed a meta-analysis or randomized controlled trials (RCTs) to evaluate the influence of oral magnesium supplementation on the incidence of preeclampsia in pregnant women. Relevant studies were obtained by search of Medline, Embase, and Cochrane's Library databases. A random effects model was used to pool the results. Influences of study characteristics of the outcome were evaluated by predefined subgroup analyses. Seven RCTs with 2653 pregnant women were included. Pooled results showed that oral magnesium supplementation during pregnancy significantly reduced the risk of preeclampsia (risk ratio [RR]: 0.76, 95% confidence interval [CI]: 0.59 to 0.98, P = 0.04) with no significant heterogeneity (P for Cochrane's Q test = 0.42, I2 = 1%). The result was not significant for the outcome of severe preeclampsia (RR: 0.54, 95% CI: 0.18 to 1.69, P = 0.29; I2 = 0%), although only two studies were available. Subgroup analysis showed that oral magnesium supplementation did not significantly reduce the risk of preeclampsia in normal pregnant women (RR: 0.91, 95% CI: 0.67 to 1.25, P = 0.57), but the preventative effect was significant in studies with normal and high-risk pregnant women (RR: 0.54, 95% CI: 0.35 to 0.83, P = 0.005; P for subgroup difference = 0.04). In conclusion, oral supplementation of magnesium may reduce the risk of preeclampsia, which may be more remarkable in high-risk pregnant women.
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