Diversity in blueberry genotypes and developmental stages enables discrepancy in the bioactive compounds, metabolites, and cytotoxicity
Das PR, Darwish AG, Ismail A, Haikal AM, Gajjar P, Balasubramani SP, Sheikh MB, Tsolova V, Soliman KFA, Sherif SM, El-Sharkawy I
Food chemistry · 19 citas
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Sin resultado de salud
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- National Institute of Food and Agriculture
- Universidad u hospital
- Fakultät für Geowissenschaften, Geographie und Astronomie, Universität Wien
- Gobierno
- National Institute on Minority Health and Health Disparities
- Gobierno
- NIMHD NIH HHS
- Subvenciones
- National Institute on Minority Health and Health Disparities (U54 MD 007582); National Institute of Food and Agriculture (1021741); National Institute of Food and Agriculture (2020-38821-31086)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2021-11-18 · Food Chem · vol. 374 · pág. 131632
- Editorial
- Elsevier BV
- Citado
- 48 citas · más que el 90% de estudios similares · 2.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Plant Gene Expression Analysis · Plant biochemistry and biosynthesis
- Palabras clave
- Nutraceutical, Quinic acid, Chlorogenic acid, Metabolite, Cultivar, Metabolomics, Malic acid, Biology, Ellagic acid, Primary metabolite, Food science, Chemistry, Antioxidant, Biochemistry, Botany, Polyphenol, Citric acid, Chromatography
- MeSH
- caco-2 cells, humans, phenols, antioxidants, genotype, blueberry plants
11 autores
- Protiva Rani Das🇺🇸Florida Agricultural and Mechanical University; Virginia Tech
- Ahmed G. Darwish🇺🇸🇪🇬Florida Agricultural and Mechanical University; Minia University
- Ahmed Ismail🇪🇬🇺🇸Damanhour University; Florida Agricultural and Mechanical University
- Amr M. Haikal🇪🇬Damanhour University
- Pranavkumar Gajjar🇺🇸Florida Agricultural and Mechanical University
- Subramani Paranthaman Balasubramani🇺🇸Albany State University; Florida Agricultural and Mechanical University
- Mehboob B. Sheikh🇺🇸Florida Agricultural and Mechanical University
- Violeta M. Tsolova🇺🇸Florida Agricultural and Mechanical University
- Karam F. A. Soliman🇺🇸Florida Agricultural and Mechanical University
- Sherif M. Sherif🇺🇸 · autor de correspondenciaVirginia Tech
- Islam El‐Sharkawy🇺🇸 · autor de correspondenciaFlorida Agricultural and Mechanical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Eight blueberry cultivars at three developmental stages were investigated for metabolite profiling, antioxidant, and anticancer activities. Cultivars- and developmental stages-variations were determined in total phenolic, flavonoid, DPPH, and FRAP antioxidant assays. The anticancer capacity was equal against A549, HepG2, and Caco-2 cancer cells, whereas the inhibition rate was dose-, incubation period-, cultivar-, and developmental stages-dependent. The untargeted metabolite profiling by UPLC-TOF-MS analysis of two contrast cultivars, 'Vernon' and 'Star', throughout the developmental stages revealed 328 metabolites; the majority of them were amino acids, organic acids, and flavonoids. The multivariate statistical analysis identified five metabolites, including quinic acid, methyl succinic acid, chlorogenic acid, oxoadipic acid, and malic acid, with positively higher correlations with all anticancer activities. This comprehensive database of blueberry metabolites along with anticancer activities could be targeted as natural anticancer potentials. This study would be of great value for food, nutraceutical, and pharmaceutical industries as well as plant biotechnologists.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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