Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
Veronese N, Dominguez LJ, Pizzol D, Demurtas J, Smith L, Barbagallo M
Nutrients · 38 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-11-15 · Nutrients · vol. 13 · número 11 · pág. 4074
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 59 citas · más que el 77% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 70 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Aluminum toxicity and tolerance in plants and animals
- Palabras clave
- Diabetes mellitus, Medicine, Placebo, Internal medicine, Endocrinology, Insulin, Randomized controlled trial, Insulin sensitivity, Confidence interval, Insulin resistance
- MeSH
- humans, diabetes mellitus, insulin resistance, magnesium, blood glucose, glucose tolerance test, treatment outcome, double-blind method, dietary supplements, randomized controlled trials as topic
6 autores
- Nicola Veronese🇮🇹 · autor de correspondenciaUniversity of Palermo
- Ligia Juliana Dominguez🇮🇹Università degli Studi di Enna Kore; University of Palermo
- Damiano Pizzol🇳🇴Norwegian Agency for Development Cooperation
- Jacopo Demurtas🇮🇹University of Modena and Reggio Emilia
- Lee H. Smith🇬🇧Anglia Ruskin University
- Mario Barbagallo🇮🇹University of Palermo
Resumen
El texto original del estudio, en el idioma en que se publicó.
There is a large and growing body of literature focusing on the use of oral magnesium (Mg) supplementation for improving glucose metabolism in people with or at risk of diabetes. We therefore aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes, compared with a placebo. Several databases were searched investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or conditions at high risk of diabetes. Data were reported as standardized mean differences (SMDs) with their 95% confidence intervals (CIs) using follow-up data of glucose and insulin-sensitivity parameters. Compared with placebo, Mg supplementation reduced fasting plasma glucose in people with diabetes. In people at high risk of diabetes, Mg supplementation significantly improved plasma glucose per se, and after a 2 h oral glucose tolerance test. Furthermore, Mg supplementation demonstrated an improvement in insulin sensitivity markers. In conclusion, Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes. Moreover, our work indicates that Mg supplementation may improve insulin-sensitivity parameters in those at high risk of diabetes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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