Ultra-processed food intake and all-cause and cause-specific mortality in individuals with cardiovascular disease: the Moli-sani Study
Bonaccio M, Costanzo S, Di Castelnuovo A, Persichillo M, Magnacca S, De Curtis A, Cerletti C, Donati MB, de Gaetano G, Iacoviello L
European heart journal · 62 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Italian Ministry of University and Research
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-10-29 · Eur Heart J · vol. 43 · número 3 · págs. 213–224
- Editorial
- Oxford University Press
- Citado
- 77 citas · más que el 99% de estudios similares · 10.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Food composition and properties
- Palabras clave
- Medicine, Disease, Cause of death, Internal medicine, Cardiology, Intensive care medicine, Environmental health
- MeSH
- humans, cardiovascular diseases, diet, cause of death, eating, aged, middle aged, female, male, fast foods
11 autores
- Marialaura Bonaccio🇮🇹 · autor de correspondenciaIstituto Neurologico Mediterraneo
- Simona Costanzo🇮🇹Istituto Neurologico Mediterraneo
- Augusto Filippo Di Castelnuovo🇮🇹Clinica Mediterranea
- Mariarosaria Persichillo🇮🇹Istituto Neurologico Mediterraneo
- Sara Magnacca🇮🇹Clinica Mediterranea
- Amalia De Curtis🇮🇹Istituto Neurologico Mediterraneo
- Chiara Cerletti🇮🇹Istituto Neurologico Mediterraneo
- Maria Benedetta Donati🇮🇹Istituto Neurologico Mediterraneo
- Giovanni de Gaetano🇮🇹Istituto Neurologico Mediterraneo
- Licia Iacoviello🇮🇹University of Insubria; Istituto Neurologico Mediterraneo
- for the Moli-sani Study Investigators
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To evaluate the association of ultra-processed food (UPF) intake and mortality among individuals with history of cardiovascular disease (CVD) and analyse some biological pathways possibly relating UPF intake to death.
Methods and results
Longitudinal analysis on 1171 men and women (mean age: 67 ± 10 years) with history of CVD, recruited in the Moli-sani Study (2005-10, Italy) and followed for 10.6 years (median). Food intake was assessed using a food frequency questionnaire. UPF was defined using the NOVA classification according to degree of processing and categorized as quartiles of the ratio (%) between UPF (g/day) and total food consumed (g/day). The mediating effects of 18 inflammatory, metabolic, cardiovascular, and renal biomarkers were evaluated using a logistic regression model within a counterfactual framework. In multivariable-adjusted Cox analyses, higher intake of UPF (Q4, ≥11.3% of total food), as opposed to the lowest (Q1, UPF <4.7%), was associated with higher hazards of all-cause (hazard ratio [HR]: 1.38; 95% confidence interval (CI): 1.00-1.91) and CVD mortality (HR: 1.65; 95% CI: 1.07-2.55). A linear dose-response relationship of 1% increment in UPF intake with all-cause and CVD mortality was also observed. Altered levels of cystatin C explained 18.3% and 16.6% of the relation between UPF (1% increment in the diet) with all-cause and CVD mortality, respectively.
Conclusion
A diet rich in UPF is associated with increased hazards of all-cause and CVD mortality among individuals with prior cardiovascular events, possibly through an altered renal function. Elevated UPF intake represents a major public health concern in secondary CVD prevention.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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