Dietary nitrate supplementation to enhance exercise capacity in hypoxic COPD: EDEN-OX, a double-blind, placebo-controlled, randomised cross-over study
Pavitt MJ, Lewis A, Buttery SC, Fernandez BO, Mikus-Lelinska M, Banya WAS, Feelisch M, Polkey MI, Hopkinson NS
Thorax · 22 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Moulton Charitable Foundation
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-12-01 · Thorax · vol. 77 · número 10 · págs. 968–975
- Editorial
- BMJ
- Citado
- 32 citas · más que el 95% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Cardiovascular and exercise physiology · Chronic Obstructive Pulmonary Disease (COPD) Research · High Altitude and Hypoxia
- Palabras clave
- Medicine, Placebo, COPD, Hypoxia (environmental), Dietary Nitrate, Nitrate, Heart rate, Nitrite, Internal medicine, Blood pressure, Surgery, Physical therapy, Oxygen, Pathology
- MeSH
- humans, pulmonary disease, chronic obstructive, nitrates, oxygen, antioxidants, cross-over studies, double-blind method, exercise tolerance, dietary supplements, adult, hypoxia
9 autores
- Matthew J. Pavitt🇺🇸🇬🇧Lung Institute; Imperial College London
- Adam P Lewis🇺🇸🇬🇧Lung Institute; Imperial College London
- Sara Catherine Buttery🇺🇸🇬🇧Lung Institute; Imperial College London
- Bernadette O. Fernandez🇺🇸Southampton Hospital
- Monika Mikus-Lelinska🇺🇸Southampton Hospital
- WINSTON A. S. BANYA🇺🇸🇬🇧Lung Institute; Imperial College London
- Martin Feelisch🇬🇧🇨🇿Southampton General Hospital; NIHR Southampton Respiratory Biomedical Research Unit; Institute of Clinical and Experimental Medicine; University of Southampton
- Michael Iain Polkey🇬🇧🇺🇸🇦🇺Royal Brompton Hospital; Lung Institute; Respiratory Clinical Trials; Imperial College London
- Nicholas S Hopkinson🇺🇸🇬🇧 · autor de correspondenciaLung Institute; Imperial College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rationale
Dietary nitrate supplementation improves skeletal muscle oxygen utilisation and vascular endothelial function. We hypothesised that these effects might be sufficient to improve exercise performance in patients with COPD and hypoxia severe enough to require supplemental oxygen.
Methods
We conducted a single-centre, double-blind, placebo-controlled, cross-over study, enrolling adults with COPD who were established users of long-term oxygen therapy. Participants performed an endurance shuttle walk test, using their prescribed oxygen, 3 hours after consuming either 140 mL of nitrate-rich beetroot juice (BRJ) (12.9 mmol nitrate) or placebo (nitrate-depleted BRJ). Treatment order was allocated (1:1) by computer-generated block randomisation.
Measurements
The primary outcome was endurance shuttle walk test time. The secondary outcomes included area under the curve to isotime for fingertip oxygen saturation and heart rate parameters during the test, blood pressure, and endothelial function assessed using flow-mediated dilatation. Plasma nitrate and nitrite levels as well as FENO were also measured.
Main results
20 participants were recruited and all completed the study. Nitrate-rich BRJ supplementation prolonged exercise endurance time in all participants as compared with placebo: median (IQR) 194.6 (147.5-411.7) s vs 159.1 (121.9-298.5) s, estimated treatment effect 62 (33-106) s (p<0.0001). Supplementation also improved endothelial function: NR-BRJ group +4.1% (-1.1% to 14.8%) vs placebo BRJ group -5.0% (-10.6% to -0.6%) (p=0.0003).
Conclusion
Acute dietary nitrate supplementation increases exercise endurance in patients with COPD who require supplemental oxygen. Trial registration number ISRCTN14888729.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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