Creatine supplementation and VO2max: a systematic review and meta-analysis
Gras D, Lanhers C, Bagheri R, Ugbolue UC, Coudeyre E, Pereira B, Zak M, Bouillon-Minois JB, Dutheil F
Critical reviews in food science and nutrition · 9 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-12-03 · Crit Rev Food Sci Nutr · vol. 63 · número 21 · págs. 4855–4866
- Editorial
- Taylor & Francis
- Citado
- 12 citas · más que el 30% de estudios similares · 0.1× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Sports Performance and Training
- Palabras clave
- creatine supplementation, VO2max, cardiorespiratory fitness, exercise performance, endurance training, dietary supplements, placebo comparison
- MeSH
- humans, creatine, exercise, dietary supplements, adult, female, male
9 autores
- Damien Gras🇫🇷Université Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand
- Charlotte Lanhers🇫🇷Université Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand
- Reza Bagheri🇮🇷University of Isfahan
- Ukadike Chris Ugbolue🇬🇧University of the West of Scotland
- Emmanuel Coudeyre🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre Hospitalier Universitaire de Clermont-Ferrand
- Bruno Pereira🇫🇷Centre Hospitalier Universitaire de Clermont-Ferrand
- Marek Žák🇵🇱Jan Kochanowski University
- Jean‐Baptiste Bouillon‐Minois🇫🇷Centre National de la Recherche Scientifique; Université Clermont Auvergne; Laboratoire de Psychologie Sociale et Cognitive; Centre Hospitalier Universitaire de Clermont-Ferrand
- Frédéric Dutheil🇫🇷 · autor de correspondenciaCentre National de la Recherche Scientifique; Université Clermont Auvergne; Laboratoire de Psychologie Sociale et Cognitive; Centre Hospitalier Universitaire de Clermont-Ferrand
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although creatine supplementation is well-known to increase exercise performance in acute high-intensity exercises, its role in aerobic performance based on VO2max is more controversial. Thus, we performed a systematic review and meta-analysis on the effects of creatine supplementation on VO2max. PubMed, Cochrane, Embase, and ScienceDirect were searched for randomized controlled trials (RCTs) reporting VO2max in creatine supplementation and placebo groups before and after supplementation. We computed a random-effects meta-analysis on VO2max at baseline, within groups following supplementation, on changes on VO2max between groups, and after supplementation between groups. Sensitivity analyses and meta-regression were conducted. We included 19 RCTs for a total of 424 individuals (mean age 30 years old, 82% men). VO2max did not differ at baseline between groups (creatine and placebo). Participants in both groups were engaged in exercise interventions in most studies (80%). Using changes in VO2max, VO2max increased in both groups but increased less after creatine supplementation than placebo (effect size [ES] = -0.32, 95%CI = -0.51 to -0.12, p = 0.002). Comparisons after creatine supplementation confirmed a lower VO2max in the creatine group compared to the placebo group (ES= -0.20, 95%CI = -0.39 to -0.001, p = 0.049). Meta-analysis after exclusion from meta-funnel resulted in similar outcomes in a subgroup of young and healthy participants. Meta-regressions on characteristics of supplementation, physical training, or sociodemographic were not statistically significant. Creatine supplementation has a negative effect on VO2max, regardless of the characteristics of training, supplementation, or population characteristics.Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2021.2008864 .
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