Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating
Ogawa T, Hoekstra SP, Kamijo YI, Goosey-Tolfrey VL, Walsh JJ, Tajima F F, Leicht CA
PloS one · 8 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- NIHR Leicester Biomedical Research Centre
- Universidad u hospital
- leicester biomedical research centre
- Universidad u hospital
- Kyoten Research Center of Sports for Persons with Impairments
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-12-09 · PLoS One · vol. 16 · número 12 · pág. e0260775
- Editorial
- Public Library of Science
- Citado
- 11 citas · más que el 65% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Thermoregulation and physiological responses · Infrared Thermography in Medicine · Heart Rate Variability and Autonomic Control
- Palabras clave
- Internal medicine, Brain-derived neurotrophic factor, Endocrinology, Platelet, Chemistry, Neurotrophic factors, Blood plasma, Whole blood, Medicine
- MeSH
- lower extremity, humans, brain-derived neurotrophic factor, heating, body temperature regulation, adult, male, cold temperature, young adult
7 autores
- Takahiro Ogawa🇯🇵Wakayama Medical University
- Sven P. Hoekstra🇬🇧Loughborough University
- Yoshi‐ichiro Kamijo🇯🇵Wakayama Medical University
- Victoria Louise Goosey-Tolfrey🇬🇧Loughborough University
- Jeremy James Walsh🇨🇦McMaster University
- Fumihiro Tajima🇬🇧🇯🇵Loughborough University; Wakayama Medical University
- Christof A. Leicht🇬🇧 · autor de correspondenciaLoughborough University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Brain-derived neurotrophic factor (BDNF) plays a key role in neuronal adaptations. While previous studies suggest that whole-body heating can elevate circulating BDNF concentration, this is not known for local heating protocols. This study investigated the acute effects of whole-body versus local passive heating on serum and plasma BDNF concentration. Using a water-perfused suit, ten recreationally active males underwent three 90 min experimental protocols: heating of the legs with upper-body cooling (LBH), whole-body heating (WBH) and a control condition (CON). Blood samples were collected before, immediately after and 1 h post-heating for the determination of serum and plasma BDNF concentration, platelet count as well as the BDNF release per platelet. Rectal temperature, cardiac output and femoral artery shear rate were assessed at regular intervals. Serum and plasma BDNF concentration were elevated after WBH (serum: 19.1±5.0 to 25.9±11.3 ng/ml, plasma: 2.74±0.9 to 4.58±2.0; p0.126), when compared with CON (serum: 18.6±6.4 to 16.8±3.4 ng/ml, plasma: 2.49±0.69 to 2.82±0.89 ng/ml); accompanied by an increase in platelet count (p<0.001). However, there was no change in BDNF content per platelet after either condition (p = 0.392). All physiological measures were elevated to a larger extent after WBH compared with LBH (p<0.001), while shear rate and rectal temperature were higher during LBH than CON (p<0.038). In conclusion, WBH but not LBH acutely elevates circulating BDNF concentration. While these findings further support the use of passive heating to elevate BDNF concentration, a larger increase in shear rate, sympathetic activity and/or rectal temperature than found after LBH appears needed to induce an acute BDNF response by passive heating.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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