Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study
Wei YF, Hao YY, Gao S, Li XQ, Liu FH, Wen ZY, Wang HY, Zhang S, Yan S, Luan M, Zhao YH, Gong TT, Wu QJ
Frontiers in nutrition · 18 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Innovative Research Group Project of the National Natural Science Foundation of China
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- China Postdoctoral Science Foundation
- Universidad u hospital
- China Medical University
- Gobierno
- Liaoning Revitalization Talents Program
- Universidad u hospital
- Shengjing Hospital
- Subvenciones
- Liaoning Revitalization Talents Program (82103914); National Natural Science Foundation of China (XLYC1907102); Liaoning Revitalization Talents Program (2017YFC0907404); Liaoning Revitalization Talents Program (XLYC1907102); National Natural Science Foundation of China (82073647); National Natural Science Foundation of China (81602918); National Natural Science Foundation of China (2017YFC0907404); Liaoning Revitalization Talents Program (82073647); National Natural Science Foundation of China (82103914); China Postdoctoral Science Foundation (2018M641752)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-11-24 · Front Nutr · vol. 8 · pág. 778031
- Editorial
- Frontiers Media
- Citado
- 20 citas · más que el 82% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Garlic and Onion Studies · Ovarian cancer diagnosis and treatment
- Palabras clave
- Medicine, Hazard ratio, Interquartile range, Cruciferous vegetables, Body mass index, Proportional hazards model, Confidence interval, Internal medicine, Cohort study, Cohort, Prospective cohort study, Confounding, Cancer
13 autores
- Yifan Wei🇨🇳China Medical University
- Yingying Hao🇨🇳China Medical University
- Song Gao🇨🇳China Medical University
- Xiuqin Li🇨🇳China Medical University
- Fang-Hua Liu🇨🇳China Medical University
- Zhao-Yan Wen🇨🇳China Medical University
- Han-Yuan Wang🇨🇳China Medical University
- Shuang Zhang🇨🇳China Medical University
- Shi Yan🇨🇳China Medical University
- Meng Luan🇨🇳China Medical University
- Yuhong Zhao🇨🇳China Medical University
- Ting‐Ting Gong🇨🇳 · autor de correspondenciaChina Medical University
- Qi‐Jun Wu🇨🇳 · autor de correspondenciaChina Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: The associations of the consumption of cruciferous vegetables (CVs) and their bioactive components, isothiocyanates (ITCs), with ovarian cancer (OC) mortality have been unclear, owing to limited studies and inconsistent findings. To date, no studies have evaluated these associations among Chinese patients with OC. This study aims to provide more evidence indicating the relationships of pre-diagnosis CVs and ITC intake with OC survival. Methods: We examined the associations of pre-diagnosis CV and ITC intake with OC mortality in a hospital-based cohort (n = 853) of Chinese patients with epithelial OC between 2015 and 2020. Pre-diagnosis dietary information was evaluated with a validated food frequency questionnaire. Deaths were ascertained until March 31, 2021 via medical records and active follow-up. The associations were examined with the Cox proportional hazards model, adjusted for potential confounders, and stratified by menopausal status, residual lesions, histological type, and body mass index (BMI). Results: During a median follow-up of 37.2 months (interquartile: 24.7-50.2 months), we observed 130 deaths. The highest tertile of total CV intake was associated with better survival than the lowest tertile intake [hazard ratio (HR) = 0.57, 95% confidence interval (CI) = 0.33-0.98, p trend T3VS.T1 = 0.59, 95% CI = 0.36-0.99, p trend = 0.06). Significant inverse associations were also observed for subgroup analyses stratified by menopausal status, residual lesions, histological type, and BMI, although not all associations showed statistical significance. Conclusion: Increasing pre-diagnosis consumption of CVs and ITCs was strongly associated with better survival in patients with OC.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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