Effects of a short-term cold exposure on circulating microRNAs and metabolic parameters in healthy adult subjects
Thibonnier M, Ghosh S, Blanchard A
Journal of cellular and molecular medicine · 6 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Louisiana Clinical and Translational Science Center
- Gobierno
- National Institutes of Health
- Gobierno
- Medical Research Council
- Gobierno
- National Medical Research Council
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- NIGMS NIH HHS
- Gobierno
- NIH HHS
- Subvenciones
- National Institute of General Medical Sciences (U54‐ GM104940); National Institute of General Medical Sciences (GM104940); Louisiana Clinical and Translational Science Center (GM104940); National Institutes of Health (NIGMS 2U54 GM104940)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-12-17 · J Cell Mol Med · vol. 26 · número 2 · págs. 548–562
- Editorial
- Wiley
- Citado
- 7 citas · más que el 48% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 62 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- MicroRNA in disease regulation · Adipose Tissue and Metabolism · Thermoregulation and physiological responses
- Palabras clave
- cold exposure, circulating microRNAs, metabolic parameters, copeptin, norepinephrine, C-peptide, cooling vest, skin temperature, healthy adults
- MeSH
- humans, cardiovascular diseases, metabolic diseases, micrornas, reproducibility of results, shivering, adult, male, cold temperature, healthy volunteers, circulating microrna
3 autores
- Marc Thibonnier · autor de correspondencia
- Sujoy Ghosh🇺🇸🇸🇬Pennington Biomedical Research Center; National University of Singapore; Duke-NUS Medical School
- Anne Blanchard🇫🇷Hôpital Européen Georges-Pompidou; Centre d'Investigation Clinique Hôpital Européen Georges Pompidou
Resumen
El texto original del estudio, en el idioma en que se publicó.
This discovery study investigated in healthy subjects whether a short-term cold exposure may alter circulating microRNAs and metabolic parameters and if co-expression networks between these factors could be identified. This open randomized crossover (cold vs no cold exposure) study with blind end- point evaluation was conducted at 1 center with 10 healthy adult male volunteers. Wearing a cooling vest perfused at 14°C for 2 h reduced the local skin temperature without triggering shivering, increased norepinephrine and blood pressure while decreasing copeptin, C-peptide and heart rate. Circulating microRNAs measured before and after wearing the cooling vest twice (4 time points) identified 196 mature microRNAs with excellent reproducibility over 72 h. Significant correlations of microRNA expression with copeptin, norepinephrine and C-peptide were found. A co-expression-based microRNA-microRNA network, as well as microRNA pairs displaying differential correlation as a function of temperature were also detected. This study demonstrates that circulating miRNAs are differentially expressed and coregulated upon cold exposure in humans, supporting their use as predictive and dynamic biomarkers of cardio-metabolic disorders.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.