The effect of local passive heating on skeletal muscle histamine concentration: implications for exercise-induced histamine release
Mangum JE, Needham KW, Sieck DC, Ely MR, Larson EA, Peck MC, Minson CT, Halliwill JR
Journal of applied physiology (Bethesda, Md. : 1985) · 13 citas
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Cómo se estudió
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- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
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- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Universidad u hospital
- University of Oregon
- Gobierno
- National Institute on Aging
- Gobierno
- National Heart, Lung, and Blood Institute
- Organización sin fines de lucro
- American Heart Association-American Stroke Association
- Gobierno
- NIA NIH HHS
- Gobierno
- HHS | NIH | National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Gobierno
- HHS | NIH | National Institute on Aging
- Subvenciones
- National Heart, Lung, and Blood Institute (HL144128); National Heart, Lung, and Blood Institute (R01 HL144128); National Institute on Aging (AG072805); National Institute on Aging (R01 AG072805); American Heart Association (17GRNT33660656555632Z); National Heart, Lung, and Blood Institute (H115027)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2021-12-23 · J Appl Physiol (1985) · vol. 132 · número 2 · págs. 367–374
- Editorial
- American Physiological Society
- Citado
- 12 citas · más que el 62% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Exercise and Physiological Responses · Mast cells and histamine · Allergic Rhinitis and Sensitization
- Palabras clave
- Histamine, Skeletal muscle, Histidine decarboxylase, Internal medicine, Endocrinology, Chemistry, Degranulation, Mast cell, Medicine, Immunology, Histidine, Biochemistry, Enzyme
- MeSH
- muscle, skeletal, humans, histamine, hyperthermia, induced, heating, histamine release
8 autores
- Joshua E. Mangum🇺🇸University of Oregon
- Karen Wiedenfeld Needham🇺🇸University of Oregon
- Dylan C. Sieck🇺🇸University of Oregon
- Matthew R. Ely🇺🇸University of Oregon
- Emily A. Larson🇺🇸University of Oregon
- Mairin Peck🇺🇸University of Oregon
- Christopher Todd Minson🇺🇸University of Oregon
- John R. Halliwill🇺🇸 · autor de correspondenciaUniversity of Oregon
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aerobic exercise induces mast cell degranulation and increases histamine formation by histidine decarboxylase, resulting in an ∼150% increase in intramuscular histamine. The purpose of this study was to determine if the increase in skeletal muscle temperature associated with exercise is sufficient to explain this histamine response. Specifically, we hypothesized that local passive heating that mimics the magnitude and time course of changes in skeletal muscle temperature observed during exercise would result in increased intramuscular histamine concentrations comparable to exercising values. Seven subjects participated in the main study in which pulsed short-wave diathermy was used to passively raise the temperature of the vastus lateralis over 60 min. Heating increased intramuscular temperature from 32.6°C [95% confidence interval (CI) 32.0°C to 33.2°C] to 38.9°C (38.7°C to 39.2°C) (P P NEW & NOTEWORTHY The "exercise signal" that triggers histamine release within active skeletal muscle during aerobic exercise is unknown. By mimicking the magnitude and time course of increasing skeletal muscle temperature observed during aerobic exercise, we demonstrate that part of the exercise-induced rise in histamine is explained by a thermal effect, with in vitro experiments suggesting this is most likely via de novo histamine formation. This thermal effect may be important in generating positive adaptations to exercise training.
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