Assessment of Vitamin D Metabolism in Patients with Cushing's Disease in Response to 150,000 IU Cholecalciferol Treatment
Povaliaeva A, Bogdanov V, Pigarova E, Zhukov A, Dzeranova L, Belaya Z, Rozhinskaya L, Mel'nichenko G, Mokrysheva N
Nutrients · 7 citas
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Russian Science Foundation
- Subvenciones
- Russian Science Foundation (19-15-00243)
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-11-30 · Nutrients · vol. 13 · número 12 · pág. 4329
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 10 citas · más que el 75% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Pituitary Gland Disorders and Treatments · Bone health and osteoporosis research
- Palabras clave
- Cholecalciferol, Vitamin D and neurology, Medicine, Endocrinology, Cushing's disease, Internal medicine, Vitamin, Metabolism, Cushing syndrome, Disease
- MeSH
- humans, pituitary acth hypersecretion, cholecalciferol, hydrocortisone, parathyroid hormone, vitamins, vitamin d, serum albumin, vitamin d-binding protein, treatment outcome, case-control studies, adult, middle aged, female, male
9 autores
- Alexandra A. Povaliaeva🇷🇺 · autor de correspondenciaEndocrinology Research Center
- Viktor P. Bogdanov🇷🇺Endocrinology Research Center
- Ekaterina Aleksandrovna Pigarova🇷🇺Endocrinology Research Center
- Artem Yu. Zhukov🇷🇺Endocrinology Research Center
- Larisa Konstantinovna Dzeranova🇷🇺Endocrinology Research Center
- Zhanna E. Belaya🇷🇺Endocrinology Research Center
- Liudmila Y. Rozhinskaya🇷🇺Endocrinology Research Center
- Galina Afanas'evna Mel'nichenko🇷🇺Endocrinology Research Center
- Natalia Mokrysheva🇷🇺Endocrinology Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
In this study we aimed to assess vitamin D metabolism in patients with Cushing's disease (CD) compared to healthy individuals in the setting of bolus cholecalciferol treatment. The study group included 30 adults with active CD and the control group included 30 apparently healthy adults with similar age, sex and BMI. All participants received a single dose (150,000 IU) of cholecalciferol aqueous solution orally. Laboratory assessments including serum vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3), free 25(OH)D, vitamin D-binding protein (DBP) and parathyroid hormone (PTH) as well as serum and urine biochemical parameters were performed before the intake and on Days 1, 3 and 7 after the administration. All data were analyzed with non-parametric statistics. Patients with CD had similar to healthy controls 25(OH)D3 levels (p > 0.05) and higher 25(OH)D3/24,25(OH)2D3 ratios (p p p > 0.05) and lower albumin levels (p 3/24,25(OH)2D3 ratio (r = 0.36, p 3 after cholecalciferol intake was similar in obese and non-obese states and lacked correlation with BMI (p > 0.05) among patients with CD, as opposed to the control group. Overall, patients with CD have a consistently higher 25(OH)D3/24,25(OH)2D3 ratio, which is indicative of a decrease in 24-hydroxylase activity. This altered activity of the principal vitamin D catabolism might influence the effectiveness of cholecalciferol treatment. The observed difference in baseline free 25(OH)D levels is not entirely clear and requires further study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.