The Effects of Almond Consumption on Inflammatory Biomarkers in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Fatahi S, Daneshzad E, Lotfi K, Azadbakht L
Advances in nutrition (Bethesda, Md.) · 21 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Subvenciones
- Tehran University of Medical Sciences and Health Services (99-3-212-51296)
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-12-23 · Adv Nutr · vol. 13 · número 5 · págs. 1462–1475
- Editorial
- Elsevier BV
- Citado
- 27 citas · más que el 62% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 69 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Fatty Acid Research and Health
- Palabras clave
- almond consumption, inflammatory markers, C-reactive protein, interleukin-6, TNF-α, ICAM-1, VCAM-1, dietary intervention, obesity, dose-response relationship, healthy adults, inflammation reduction, nut intake, cardiovascular risk factors, adiponectin, AdipoR1, AdipoR2, adiponectin/insulin ratio
- MeSH
- humans, inflammation, tumor necrosis factor-alpha, c-reactive protein, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, interleukin-6, dietary supplements, adult, randomized controlled trials as topic, biomarkers, prunus dulcis
4 autores
- Shahin Fatahi🇮🇷Tehran University of Medical Sciences
- Elnaz Daneshzad🇮🇷Alborz University of Medical Sciences
- Keyhan Lotfi🇮🇷Tehran University of Medical Sciences
- Leila Azadbakht🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences; Endocrinology and Metabolism Clinical Sciences Institute; Diabetes Research Center; Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Conflicting findings have been reported regarding the effects of almond consumption on inflammatory markers. This study aimed to summarize the current literature to determine whether almonds can affect inflammatory markers. A systematic search was carried out in PubMed, Scopus, and ISI Web of Science up to March 2021. Randomized clinical trials that compared almond with no almond consumption were included. The outcomes of interest were changes in circulating C-reactive protein (CRP), IL-6, TNF-α, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) concentrations. The random-effects model was used to find the mean differences. In total, 18 trials with 847 participants were eligible for the current analysis. Participants' ages ranged from 26.3 to 69.6 y. Combining 16 studies, almond consumption significantly reduced serum concentrations of CRP [weighted mean difference (WMD): -0.25 mg/L; 95% CI: -0.43, -0.06 mg/L; I2 = 0.0%; P-heterogeneity = 0.633]. However, the beneficial effect of almond intake only occurred at doses <60 g/d. Pooling 11 effect sizes, almond interventions significantly decreased circulating IL-6 concentrations (WMD: -0.11 pg/mL; 95% CI: -0.21, -0.01 pg/mL; I2 = 19.9%; P-heterogeneity = 0.254). In subgroup analyses, effects on CRP and IL-6 were nonsignificant in unhealthy participants or those with obesity. In addition, almond consumption had no significant effect on TNF-α (WMD: -0.05 pg/mL; 95% CI: -0.11, 0.01 pg/mL; I2 = 0.0%; P-heterogeneity = 0.893; n = 6), ICAM-1 (WMD: 6.39 ng/mL; 95% CI: -9.44, 22.22 ng/mL; I2 = 66.6%; P-heterogeneity = 0.006; n = 7), or VCAM-1 (WMD: -8.31 ng/mL; 95% CI: -35.32, 18.71 ng/mL; I2 = 58.8%; P-heterogeneity = 0.033; n = 6). In conclusion, almond consumption beneficially affects CRP and IL-6 concentrations in adults. However, it has no beneficial effect on TNF-α, ICAM-1, or VCAM-1. More trials are needed to determine the effects of almonds on inflammation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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