Evaluation of the Anti-constipation Effects of Abdominal Application of Olive Oil Ointment in Children 1-4 Years Old: A Pilot Placebo-Controlled, Double-Blind, Randomized Clinical Trial
Arman-Asl H, Mohammadpour AH, Hamedi A, Emami SA, Abbaspour M, Sahebkar A, Javadi B
Advances in experimental medicine and biology · 4 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-01-01 · Adv Exp Med Biol · vol. 1328 · págs. 411–419
- Editorial
- Springer Nature
- Citado
- 3 citas · más que el 97% de estudios similares · 6.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 21 trabajos
- Acceso
- De pago
- Áreas de investigación
- Gastrointestinal motility and disorders · Pelvic floor disorders treatments · Complementary and Alternative Medicine Studies
- Palabras clave
- functional constipation, pediatric constipation, Persian medicine, stool frequency, fecal impaction, herbal products
- MeSH
- humans, constipation, ointments, treatment outcome, double-blind method, defecation, child, child, preschool, infant, laxatives, olive oil
7 autores
- Hossein Arman-Asl🇮🇷Mashhad University of Medical Sciences
- Amir Hooshang Mohammadpour🇮🇷Mashhad University of Medical Sciences
- Abdolkarim Hamedi🇮🇷Mashhad University of Medical Sciences
- Seyed Ahmad Emami🇮🇷Mashhad University of Medical Sciences
- Mohammadreza Abbaspour🇮🇷Mashhad University of Medical Sciences
- Amirhossein Sahebkar🇮🇷🇵🇱Mashhad University of Medical Sciences; Polish Mother’s Memorial Hospital Research Institute
- Behjat Javadi🇮🇷 · autor de correspondenciaMashhad University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
With a prevalence of 0.7 to 29.6%, functional constipation (FC) is a common pediatric complaint worldwide. Current therapeutic strategies for FC mainly include prevention and treatment of fecal impaction, by administration of oral laxatives or rectal medications. However, these agents have been reported to have limited efficacy and a number of serious side effects. In traditional Persian medicine, local application of olive oil was used to relieve childhood constipation. In this pilot placebo-controlled, double-blind, randomized clinical trial, the laxative effects of the external use of olive oil ointment in 1- to 4-year-old children with functional constipation were investigated.
Methods and materials
Forty patients with FC were randomly assigned in olive oil ointment or placebo groups, receiving either an ointment containing 85% olive oil or a comparable placebo or an ointment containing 85% liquid paraffin adjusted to have color and odor similar to those of intervention ointment, twice a day for 4 days. Rome III criteria for functional gastrointestinal disorders (FGIDs) were used to identify eligible patients from three hospitals. The primary outcome measure was treatment success, defined as ≥1 spontaneous stools per day, without episodes of fecal impaction at endpoint (day 4). The secondary outcome measure was the frequency of fecal incontinence, abdominal discomfort or flatulence, painful defecation, and dermal irritations (adverse effect).
Results
Improvements in stool frequency started from day 1 and continued up to day 4 (end of the study) and were significantly greater in patients receiving olive oil ointment in comparison with placebo group (p < 0.05). No adverse effect (including fecal incontinence, painful defecation, gripe and skin reaction, etc.) was reported in intervention and placebo groups during the study.
Conclusion
Olive oil ointment used in this study can be presented as a safe, well-tolerated, and effective herbal preparation in children with functional constipation.
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