Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial
Power R, Nolan JM, Prado-Cabrero A, Roche W, Coen R, Power T, Mulcahy R
Clinical nutrition (Edinburgh, Scotland) · 79 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- George A. and Eliza Gardner Howard Foundation
- Gobierno
- Science Foundation Ireland
- Gobierno
- Department of Agriculture, Australian Government
- Subvenciones
- Department of Agriculture, Australian Government (16/RC/3835 —VistaMilk); Department of Agriculture, Australian Government (16/RC/3835); George A. and Eliza Gardner Howard Foundation (285822)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2021-12-07 · Clin Nutr · vol. 41 · número 2 · págs. 405–414
- Editorial
- Elsevier BV
- Citado
- 112 citas · más que el 99% de estudios similares · 8.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Fatty Acid Research and Health · Dementia and Cognitive Impairment Research · Antioxidant Activity and Oxidative Stress
- Palabras clave
- omega-3 fatty acids, fish oil supplementation, docosahexaenoic acid, eicosapentaenoic acid, carotenoids, lutein, meso-zeaxanthin, zeaxanthin, vitamin E, working memory, older adults, cognitive performance, cognitive decline, dementia risk, xanthophyll carotenoids
- MeSH
- humans, carotenoids, vitamin e, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, fish oils, double-blind method, memory, short-term, neuropsychological tests, dietary supplements, aged, middle aged, female, male, zeaxanthins
7 autores
- Rebecca Power🇮🇪 · autor de correspondenciaWaterford Institute of Technology
- John M. Nolan🇮🇪 · autor de correspondenciaWaterford Institute of Technology
- Alfonso Prado‐Cabrero🇮🇪 · autor de correspondenciaWaterford Institute of Technology
- Warren Roche🇮🇪 · autor de correspondenciaWaterford Institute of Technology
- Robert F. Coen🇮🇪 · autor de correspondenciaSt. James's Hospital
- Tommy Power🇮🇪 · autor de correspondenciaWaterford Institute of Technology
- Ríona Mulcahy🇮🇪 · autor de correspondenciaRoyal College of Surgeons in Ireland; University Hospital Waterford; Health Service Executive
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Accumulating evidence suggests that omega-3 fatty acids (ω-3FAs), carotenoids and vitamin E can improve cognitive performance. However, their collective impact on cognition has not yet been investigated in healthy individuals. This study investigated the combined effect of ω-3FA, carotenoid and vitamin E supplementation on the cognitive performance of older adults.
Methods
Cognitively healthy individuals aged ≥65 years consumed daily 1 g fish oil (of which 430 mg docosahexaenoic acid, 90 mg eicosapentaenoic acid), 22 mg carotenoids (10 mg lutein, 10 mg meso-zeaxanthin, 2 mg zeaxanthin) and 15 mg vitamin E or placebo for 24 months in a double-blind, placebo-controlled, randomised clinical trial.
Results
Following 24-month supplementation, individuals in the active group (n = 30; aged 69.03 ± 4.41 years; 56.7% female) recorded significantly fewer errors in working memory tasks than individuals receiving placebo (n = 30; aged 69.77 ± 3.74 years; 70% female) (point estimate effect sizes ranged 0.090-0.105). Interestingly, as the cognitive load of the working memory tasks increased, the active group outperformed the placebo group. Statistically significant improvements in tissue carotenoid concentrations, serum xanthophyll carotenoid concentrations and plasma ω-3FA concentrations were also observed in the active group versus placebo (point estimate effect sizes ranged 0.078-0.589). Moreover, the magnitude of change of carotenoid concentrations in tissue, and ω-3FA and carotenoid concentrations in blood were related to the magnitude of change in working memory performance.
Conclusion
These results support a biologically plausible rationale whereby these nutrients work synergistically, and in a dose-dependent manner, to improve working memory in cognitively healthy older adults. Increasing nutritional intake of carotenoids and ω-3FAs may prove beneficial in reducing cognitive decline and dementia risk in later life.
Study id number
ISRCTN10431469; https://doi.org/10.1186/ISRCTN10431469.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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