Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies
Liu D, Meng X, Tian Q, Cao W, Fan X, Wu L, Song M, Meng Q, Wang W, Wang Y
Advances in nutrition (Bethesda, Md.) · 97 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- China Scholarship Council
- Gobierno
- National Health and Medical Research Council
- Gobierno
- China–Australian Collaborative Grant
- Subvenciones
- National Natural Science Foundation of China (NSFC 81872682); National Natural Science Foundation of China (NHMRC APP1112767); National Natural Science Foundation of China (NSFC81561128020); National Natural Science Foundation of China ([81561128020–NHMRC APP1112767); National Natural Science Foundation of China (NSFC 81773527); China Scholarship Council (NSFC 81561128020-NHMRC APP1112767); China Scholarship Council (CSC 201908110339); National Natural Science Foundation of China (81561128020); National Natural Science Foundation of China (81773527); National Natural Science Foundation of China (APP1112767); National Health and Medical Research Council (NSFC 81561128020); National Health and Medical Research Council (NHMRCAPP1112767); National Health and Medical Research Council (1112767); National Natural Science Foundation of China (81872682); China Scholarship Council (201908110339)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2021-11-19 · Adv Nutr · vol. 13 · número 4 · págs. 1044–1062
- Editorial
- Elsevier BV
- Citado
- 121 citas · más que el 99% de estudios similares · 9.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 346 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Nutritional Studies and Diet
- Palabras clave
- vitamin D, vitamin D supplementation, vitamin D deficiency, all-cause mortality, Alzheimer's disease, hypertension, schizophrenia, type 2 diabetes, chronic disease prevention
- MeSH
- humans, alzheimer disease, hypertension, diabetes mellitus, type 2, vitamins, vitamin d, dietary supplements, randomized controlled trials as topic, mendelian randomization analysis, systematic reviews as topic
10 autores
- Di Liu🇨🇳Capital Medical University; Chinese Academy of Sciences; Shenzhen Institutes of Advanced Technology
- Xiaoni Meng🇨🇳Capital Medical University
- Qiuyue Tian🇨🇳Capital Medical University
- Weijie Cao🇨🇳Capital Medical University
- Xin Fan🇨🇳Capital Medical University
- Lijuan Wu🇨🇳Capital Medical University
- Manshu Song🇦🇺Edith Cowan University
- Qun Meng🇨🇳Capital Medical University
- Wei Qiang Wang🇦🇺🇨🇳Edith Cowan University; Capital Medical University; Shandong First Medical University
- Youxin Wang🇦🇺🇨🇳 · autor de correspondenciaEdith Cowan University; Capital Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Observational studies, randomized controlled trials (RCTs), and Mendelian randomization (MR) studies have yielded inconsistent results on the associations of vitamin D concentrations with multiple health outcomes. In the present umbrella review we aimed to evaluate the effects of low vitamin D concentrations and vitamin D supplementation on multiple health outcomes. We summarized current evidence obtained from meta-analyses of observational studies that examined associations between vitamin D concentrations and multiple health outcomes, meta-analyses of RCTs that investigated the effect of vitamin D supplementation on multiple health outcomes, and MR studies that explored the causal associations of vitamin D concentrations with various diseases (international prospective register of systematic reviews PROSPERO registration number CRD42018091434). A total of 296 meta-analyses of observational studies comprising 111 unique outcomes, 139 meta-analyses of RCTs comprising 46 unique outcomes, and 73 MR studies comprising 43 unique outcomes were included in the present umbrella review. Twenty-eight disease outcomes were identified by both meta-analyses of observational studies and MR studies. Seventeen of these reported disease outcomes had consistent results, demonstrating that lower concentrations of vitamin D were associated with a higher risk for all-cause mortality, Alzheimer's disease, hypertension, schizophrenia, and type 2 diabetes. The combinations of consistent evidence obtained by meta-analyses of observational studies and MR studies together with meta-analyses of RCTs showed that vitamin D supplementation was associated with a decreased risk for all-cause mortality but not associated with the risk for Alzheimer's disease, hypertension, schizophrenia, or type 2 diabetes. The results indicated that vitamin D supplementation is a promising strategy with long-term preventive effects on multiple chronic diseases and thus has the potential to decrease all-cause mortality. However, the current vitamin D supplementation strategy might not be an efficient intervention approach for these diseases, suggesting that new strategies are highly needed to improve the intervention outcomes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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