Cashew oral immunotherapy for desensitizing cashew-pistachio allergy (NUT CRACKER study)
Elizur A, Appel MY, Nachshon L, Levy MB, Epstein-Rigbi N, Koren Y, Holmqvist M, Porsch H, Lidholm J, Goldberg MR
Allergy · 44 citas
Etiquetas de revisión
Alimentación controladaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Health, State of Israel
Según 1 financiador declarado.
Publicación
- Publicado
- 2022-01-09 · Allergy · vol. 77 · número 6 · págs. 1863–1872
- Editorial
- Wiley
- Citado
- 56 citas · más que el 98% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Food Allergy and Anaphylaxis Research · Respiratory and Cough-Related Research · Oral Health Pathology and Treatment
- Palabras clave
- Oral immunotherapy, Allergy, Immunotherapy, Immunopathology, Respiratory Hypersensitivity
- MeSH
- humans, anacardium, pistacia, nut hypersensitivity, immunotherapy, desensitization, immunologic, administration, oral, child, preschool
10 autores
- Arnon Elizur🇮🇱 · autor de correspondenciaTel Aviv University; Assaf Harofeh Medical Center
- Michael Y. Appel🇮🇱Assaf Harofeh Medical Center
- Liat Nachshon🇮🇱Tel Aviv University; Assaf Harofeh Medical Center
- Michael B. Levy🇮🇱Assaf Harofeh Medical Center
- Naama Epstein‐Rigbi🇮🇱Tel Aviv University; Assaf Harofeh Medical Center
- Yael Koren🇮🇱Assaf Harofeh Medical Center
- Marie Holmqvist🇸🇪Thermo Fisher Scientific (Sweden)
- Helena Porsch🇸🇪Thermo Fisher Scientific (Sweden)
- Jonas Lidholm🇸🇪Thermo Fisher Scientific (Sweden)
- Michael R. Goldberg🇮🇱Tel Aviv University; Assaf Harofeh Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Oral immunotherapy (OIT) is a treatment option for patients with milk, egg, and peanut allergy, but data on the efficacy and safety of cashew OIT are limited.
Methods
A cohort of 50 cashew-allergic patients aged ≥4 years, who were consecutively enrolled into cashew OIT (target dose 4000 mg protein) between 4/2016 and 12/2019. Fifteen cashew-allergic patients who continued cashew elimination served as observational controls. Co-allergy to pistachio and walnut was determined. Full desensitization rate and associated immunological changes in both groups were compared. Patients fully desensitized to cashew were instructed to consume a dose of 1200 mg cashew protein for 6 months and were then challenged to a full dose. Patients with co-allergy to pistachio or walnut were challenged to the respective nut.
Results
Forty-four of 50 OIT-treated patients (88%) compared to 0% in controls tolerated a dose of 4000 mg cashew protein at the end of the study (odds ratio 8.3, 95% CI 3.9-17.7, p < 0.001). An additional three patients were desensitized to 1200 mg cashew protein, and three patients stopped treatment. Three patients (6%) were treated with injectable epinephrine for home reactions. Desensitized patients had decreased SPT, sIgE, basophil reactivity, and increased sIgG4, following treatment. Following cashew desensitization, all pistachio (n = 35) and four of eight walnut co-allergic patients were cross-desensitized to the respective nut. All (n = 44) patients consuming a low cashew dose for ≥6 months following desensitization passed a full-dose cashew OFC.
Conclusions
Cashew OIT desensitizes most cashew-allergic patients and cross-desensitizes to pistachio. Safety is similar to OIT for other foods.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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