Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes
Chiodini I, Gatti D, Soranna D, Merlotti D, Mingiano C, Fassio A, Adami G, Falchetti A, Eller-Vainicher C, Rossini M, Persani L, Zambon A, Gennari L
Frontiers in public health · 122 citas
Etiquetas de revisión
Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministero della Salute
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Ministero della Salute (2020-RCR-2020–23670065); Ministero della Salute (RCR-2020-23670065); Ministero della Salute (23670065)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-12-22 · Front Public Health · vol. 9 · pág. 736665
- Editorial
- Frontiers Media
- Citado
- 159 citas · más que el 100% de estudios similares · 19.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 123 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · COVID-19 Clinical Research Studies · SARS-CoV-2 and COVID-19 Research
- Palabras clave
- vitamin D status, 25-hydroxyvitamin D, vitamin D deficiency, vitamin D insufficiency, COVID-19 pandemic, COVID-19 severity, COVID-19 mortality, intensive care unit admission, acute respiratory distress syndrome, hospitalization
- MeSH
- humans, vitamin d deficiency, vitamin d, rna, viral, covid-19, sars-cov-2
13 autores
- Iacopo Chiodini🇮🇹 · autor de correspondenciaUniversity of Milan; IRCCS Istituto Auxologico Italiano
- Davide Gatti🇮🇹University of Verona
- Davide Soranna🇮🇹IRCCS Istituto Auxologico Italiano
- Daniela Merlotti🇮🇹University of Siena
- Christian Mingiano🇮🇹University of Siena
- Angelo Fassio🇮🇹University of Verona
- Giovanni Adami🇮🇹University of Verona
- Alberto Falchetti🇮🇹IRCCS Istituto Auxologico Italiano
- Cristina Eller-Vainicher🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Maurizio Rossini🇮🇹University of Verona
- Luca Persani🇮🇹University of Milan; IRCCS Istituto Auxologico Italiano
- Antonella Zambon🇮🇹IRCCS Istituto Auxologico Italiano; University of Milano-Bicocca
- Luigi Gennari🇮🇹University of Siena
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Several studies suggest an association between serum 25-hydroxyvitamin D (25OHD) and the outcomes of Severe Acute Respiratory Syndrome Corona-Virus-2 (SARS-CoV-2) infection, in particular Coronavirus Disease-2019 (COVID-19) related severity and mortality. The aim of the present meta-analysis was to investigate whether vitamin D status is associated with the COVID-19 severity, defined as ARDS requiring admission to intensive care unit (ICU) or mortality (primary endpoints) and with the susceptibility to SARS-CoV-2 and COVID-19-related hospitalization (secondary endpoints). Methods: A search in PubMed, ScienceDirect, Web of Science, Google Scholar, Scopus, and preprints repositories was performed until March 31th 2021 to identify all original observational studies reporting association measures, or enough data to calculate them, between Vitamin D status (insufficiency Findings: Fifty-four studies (49 as fully-printed and 5 as pre-print publications) were included for a total of 1,403,715 individuals. The association between vitamin D status and SARS-CoV2 infection, COVID-19 related hospitalization, COVID-19 related ICU admission, and COVID-19 related mortality was reported in 17, 9, 27, and 35 studies, respectively. Severe deficiency, deficiency and insufficiency of vitamin D were all associated with ICU admission (odds ratio [OR], 95% confidence intervals [95%CIs]: 2.63, 1.45-4.77; 2.16, 1.43-3.26; 2.83, 1.74-4.61, respectively), mortality (OR, 95%CIs: 2.60, 1.93-3.49; 1.84, 1.26-2.69; 4.15, 1.76-9.77, respectively), SARS-CoV-2 infection (OR, 95%CIs: 1.68, 1.32-2.13; 1.83, 1.43-2.33; 1.49, 1.16-1.91, respectively) and COVID-19 hospitalization (OR, 95%CIs 2.51, 1.63-3.85; 2.38, 1.56-3.63; 1.82, 1.43-2.33). Considering specific subgroups (i.e., Caucasian patients, high quality studies, and studies reporting adjusted association estimates) the results of primary endpoints did not change. Interpretations: Patients with low vitamin D levels present an increased risk of ARDS requiring admission to intensive care unit (ICU) or mortality due to SARS-CoV-2 infection and a higher susceptibility to SARS-CoV-2 infection and related hospitalization.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.