Role of Whole Grain Consumption in Glycaemic Control of Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Xu D, Fu L, Pan D, Lu Y, Yang C, Wang Y, Wang S, Sun G
Nutrients · 24 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Postgraduate Research＆Practice Innovation Program of Jiangsu Province
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-12-27 · Nutrients · vol. 14 · número 1 · pág. 109
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 28 citas · más que el 66% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Celiac Disease Research and Management · Nutritional Studies and Diet
- Palabras clave
- Medicine, Randomized controlled trial, Meta-analysis, Cochrane Library, Internal medicine, Insulin resistance, Area under the curve, Whole grains, Observational study, Plasma glucose, Insulin, Gastroenterology, Endocrinology, Food science, Chemistry
- MeSH
- humans, diabetes mellitus, blood glucose, diet, whole grains, glycemic control
8 autores
- Dengfeng Xu🇨🇳Southeast University
- Lingmeng Fu🇨🇳Zhejiang Provincial People's Hospital
- Da Pan🇨🇳Southeast University
- Yifei Lü🇨🇳Southeast University
- Chao Yang🇨🇳Southeast University
- Yuanyuan Wang🇨🇳Southeast University
- Shaokang Wang🇨🇳Southeast University
- Guiju Sun🇨🇳 · autor de correspondenciaSoutheast University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Observational studies have indicated beneficial effects of whole grain consumption on human health. However, no evidence based on randomized controlled trials has been established. Our objective was to perform a systematic review and meta-analysis of randomized controlled trials to assess the effects of whole grain consumption in glycaemic control of diabetic patients.
Methods
A comprehensive search in four databases (Web of Science, Pubmed, Scopus and Cochrane library) was conducted to collect potential articles which measured the roles of whole grain consumption on glycaemic control up to October 2021.
Results
A total of 16 eligible trials involving 1068 subjects were identified to evaluate the pooled effect. The overall results indicated that compared with the control group, whole grain intake presented a significantly reduced concentration in fast plasma glucose (WMD = -0.51 mmol/L, 95% CI: -0.73, -0.28; I2 = 88.6%, p 2, 95% CI: -0.73, -0.04; I2 = 58.4%, p = 0.014), and glycosylated haemoglobin (WMD = -0.56%, 95% CI: -0.88, -0.25, I2 = 88.5%, p p = 0.120). In terms of incremental area under the curve (iAUC), data suggested that whole grain effected a significant decrease in Glucose-iAUC (WMD = -233.09 min × mmol/L, 95% CI: -451.62, -14.57; I2 = 96.1%, p p = 0.002), although only in a small number of studies. Of note, there is evidence for modest unexplained heterogeneity in the present meta-analysis.
Conclusion
Whole grain consumption confers a beneficial effect on glucose metabolism in patients with diabetes. Regrettably, since relevant studies were scarce, we failed to provide confident evidence of whole grain consumption on acute effects including Glucose-iAUC and Insulin-iAUC, which should be addressed in further trials.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.