Nutritional Status Predicts Fatty Acid Uptake from Fish and Soybean Oil Supplements for Treatment of Cancer-Related Fatigue: Results from a Phase II Nationwide Study
Kleckner AS, Culakova E, Kleckner IR, Belcher EK, Demark-Wahnefried W, Parker EA, Padula GDA, Ontko M, Janelsins MC, Mustian KM, Peppone LJ
Nutrients · 12 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Cancer Society
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Gobierno
- Maryland Department of Health's Cigarette Restitution Fund Program
- Gobierno
- Maryland Department of Health's Cigarette Restitution Fund Program
- Subvenciones
- National Cancer Institute (R03CA175599); National Cancer Institute (K07CA221931); National Cancer Institute (UG1CA189961); National Cancer Institute (CRP-19-175-06-COUN); National Cancer Institute (P30-CA134274); American Cancer Society (CRP-19-175-06-COUN); National Cancer Institute (T32CA102618)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-12-31 · Nutrients · vol. 14 · número 1 · pág. 184
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 32 citas · más que el 92% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Cancer survivorship and care · Nutrition and Health in Aging
- Palabras clave
- cancer-related fatigue, fish oil supplementation, soybean oil, omega-3 fatty acids, nutritional status, malnutrition, breast cancer survivors, serum fatty acids, controlling nutritional status, dietary fat supplementation
- MeSH
- humans, breast neoplasms, fatigue, fatty acids, omega-3, soybean oil, fatty acids, fish oils, body mass index, nutritional status, dietary supplements, aged, middle aged, female
11 autores
- Amber S. Kleckner🇺🇸 · autor de correspondenciaUniversity of Maryland, Baltimore
- Eva Culakova🇺🇸University of Rochester Medicine; University of Rochester
- Ian R. Kleckner🇺🇸University of Maryland, Baltimore
- Elizabeth K. Belcher🇺🇸Hobart and William Smith Colleges
- Wendy Demark‐Wahnefried🇺🇸University of Alabama at Birmingham
- Elizabeth A. Dennis Parker🇺🇸University of Maryland, Baltimore
- Gilbert D. A. Padula
- Mary Ontko🇺🇸Dayton Clinical Oncology Program
- Michelle C. Janelsins🇺🇸University of Rochester Medicine; University of Rochester
- Karen Michelle Mustian🇺🇸University of Rochester Medicine; University of Rochester
- Luke Joseph Peppone🇺🇸University of Rochester Medicine; University of Rochester
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cancer-related fatigue is a prevalent and debilitating condition that persists for years into survivorship. Studies evaluating both fish oil supplementation on fatigue and associations between fish oil consumption and fatigue have shown mixed effects; it is unknown what factors contribute to these differential effects. Herein, we investigate whether the nutritional status of cancer survivors was associated with serum omega-3 concentration or change in serum omega-3s throughout a fish oil supplementation study, and then if any of these factors were associated with fatigue. Breast cancer survivors 4-36 months post-treatment with moderate-severe fatigue were randomized to take 6 g fish oil, 6 g soybean oil, or 3 g of each daily for 6 weeks. Baseline nutritional status was calculated using the Controlling Nutritional Status tool (serum albumin, lymphocytes, cholesterol). At baseline and post-intervention, serum fatty acids were quantified and fatigue was assessed using the Multidimensional Fatigue Symptom Inventory. Participants (n = 85) were 61.2 ± 9.7 years old with a body mass index of 31.9 ± 6.7 kg/m2; 69% had a good nutritional score and 31% had light-moderate malnutrition. Those with good nutritional status had greater total serum omega-3s at baseline (p = 0.013) and a greater increase in serum omega-3s with supplementation (p = 0.003). Among those who were supplemented with fish oil, greater increases in serum omega-3s were associated with greater improvements in fatigue. In conclusion, good nutritional status may increase uptake of fatty acid supplements, increasing their ability to improve fatigue.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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