Olive oil intake and cancer risk: A systematic review and meta-analysis
Markellos C, Ourailidou ME, Gavriatopoulou M, Halvatsiotis P, Sergentanis TN, Psaltopoulou T
PloS one · 57 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-01-11 · PLoS One · vol. 17 · número 1 · pág. e0261649
- Editorial
- Public Library of Science
- Citado
- 78 citas · más que el 97% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 101 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Edible Oils Quality and Analysis · Nuts composition and effects
- Palabras clave
- Medicine, Meta-analysis, Relative risk, Cohort study, Internal medicine, Cancer, Subgroup analysis, Mediterranean diet, Prospective cohort study, Confidence interval
- MeSH
- humans, neoplasms, breast neoplasms, gastrointestinal neoplasms, urologic neoplasms, risk factors, case-control studies, databases, factual, female, olive oil
6 autores
- Christos Markellos🇬🇷National and Kapodistrian University of Athens; Alexandra Hospital
- Maria-Eleni Ourailidou🇬🇷National and Kapodistrian University of Athens; Alexandra Hospital
- Maria Gavriatopoulou🇬🇷National and Kapodistrian University of Athens; Alexandra Hospital
- Panagiotis Halvatsiotis🇬🇷University General Hospital Attikon
- Theodoros Ν. Sergentanis🇬🇷National and Kapodistrian University of Athens; Alexandra Hospital
- Theodora Psaltopoulou🇬🇷 · autor de correspondenciaNational and Kapodistrian University of Athens; Alexandra Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Research evidence has established the beneficial effects of diet in cancer prevention; various epidemiological studies have suggested that olive oil component could play a role in decreasing cancer risk. This systematic review and meta-analysis aims to investigate the association between olive oil consumption, cancer risk and prognosis.
Methods
A systematic search was conducted in PubMed, EMBASE and Google Scholar databases (end-of-search: May 10, 2020). Pooled relative risk (RR) and 95% confidence intervals (95% CIs) were estimated with random-effects (DerSimonian-Laird) models. Subgroup analyses, sensitivity analyses and meta-regression analysis were also performed.
Results
45 studies were included in the meta-analysis; 37 were case-control (17,369 cases and 28,294 controls) and 8 were cohort studies (12,461 incident cases in a total cohort of 929,771 subjects). Highest olive oil consumption was associated with 31% lower likelihood of any cancer (pooled RR = 0.69, 95%CI: 0.62-0.77), breast (RR = 0.67, 95%CI: 0.52-0.86), gastrointestinal (RR = 0.77, 95%CI: 0.66-0.89), upper aerodigestive (RR = 0.74, 95%CI: 0.60-0.91) and urinary tract cancer (RR = 0.46, 95%CI: 0.29-0.72). Significant overall effects spanned both Mediterranean and non-Mediterranean participants, studies presenting a multivariate and a univariate analysis and all subgroups by study quality.
Conclusions
Olive oil consumption seems to exert beneficial actions in terms of cancer prevention. Additional prospective cohort studies on various cancer types and survivors, as well as large randomized trials, seem desirable.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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