The effect of preoperative oral magnesium oxide on the severity of postoperative pain among women undergoing hysterectomy
Hashemian M, Mirkheshti A, Mirafzal A, Ahmadipour H, Nasehabad MA
Irish journal of medical science · 1 cita
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-01-12 · Ir J Med Sci · vol. 191 · número 6 · págs. 2711–2716
- Editorial
- Springer Science+Business Media
- Citado
- 3 citas · más que el 56% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- De pago
- Áreas de investigación
- Anesthesia and Pain Management · Pain Management and Opioid Use · Anesthesia and Sedative Agents
- Palabras clave
- magnesium oxide, preoperative analgesia, postoperative pain, hysterectomy, naproxen, preemptive analgesia, gynecologic surgery, analgesic use
- MeSH
- humans, magnesium oxide, naproxen, analgesics, hysterectomy, double-blind method, female, postoperative pain
5 autores
- Morteza Hashemian🇮🇷 · autor de correspondenciaKerman University of Medical Sciences
- Alireza Mirkheshti🇮🇷Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Amirhossein Mirafzal🇮🇷Kerman University of Medical Sciences
- Habibeh Ahmadipour🇮🇷Kerman University of Medical Sciences
- Mohammad Amirhosseini Nasehabad🇮🇷Kerman University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Magnesium sulfate has been reported to be effective in perioperative pain treatment and in blunting somatic, autonomic, and endocrine reflexes provoked by noxious stimuli. The pre-emptive analgesic effects of magnesium in reducing postoperative pain could be beneficial in abdominal and gynecologic surgeries.
Objective
The aim of study was to compare the pre-emptive analgesic effects of oral magnesium oxide and naproxen for hysterectomy surgery.
Methods
This study evaluated all patients who were candidates for hysterectomy in 2 months. The 64 patients were randomly divided into two groups using a random allocation sequence. The patients in the intervention and control groups received either magnesium oxide tablet (500 mg) or naproxen tablet (500 mg) orally half an hour before surgery, respectively. The severity of postoperative pain is assumed as a primary outcome which is evaluated using the visual analogue scale (VAS).
Results
In this study, 64 patients were assessed. The results showed age, weight, systolic and diastolic blood pressure, and pulse rate of the patients in the two groups were not significantly different (p > 0.05). The mean score of pain intensity for these patients was significantly lower than the patients receiving naproxen (p-value: 0.03). Besides, more than one-quarter of patients in the magnesium oxide group (n = 9, 28.12%) received this analgesia with lower dose than the patients in the naproxen group (p-value: 0.03).
Conclusion
The results of this study showed that preoperative oral magnesium oxide had a significant effect on the severity of postoperative pain and consumption of postoperative analgesia.
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