Time course of human skeletal muscle nitrate and nitrite concentration changes following dietary nitrate ingestion
Kadach S, Piknova B, Black MI, Park JW, Wylie LJ, Stoyanov Z, Thomas SM, McMahon NF, Vanhatalo A, Schechter AN, Jones AM
Nitric oxide : biology and chemistry · 37 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Exeter
- Universidad u hospital
- University of Queensland
- Gobierno
- National Institutes of Health
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Gobierno
- Intramural NIH HHS
- Subvenciones
- Biotechnology and Biological Sciences Research Council (BB/S020632/1); National Institutes of Health (Z99 DK999999); Biotechnology and Biological Sciences Research Council (BB/S020632/1)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2022-01-13 · Nitric Oxide · vol. 121 · págs. 1–10
- Editorial
- Elsevier BV
- Citado
- 44 citas · más que el 96% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Cardiovascular and exercise physiology · Pharmacological Effects and Assays
- Palabras clave
- Ingestion, Skeletal muscle, Internal medicine, Nitrite, Endocrinology, Nitric oxide, Chemistry, Bolus (digestion), Urine, Nitrate, Vastus lateralis muscle, Animal science, Medicine, Biology
- MeSH
- muscle, skeletal, humans, nitrates, nitrites, time factors, dietary supplements, adult, female, male, young adult
11 autores
- Stefan Kadach🇬🇧University of Exeter
- Barbora Piknova🇺🇸National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases
- Matthew I. Black🇬🇧University of Exeter
- Ji Won Park🇺🇸National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases
- Lee J. Wylie🇬🇧University of Exeter
- Zdravko Stoyanov🇬🇧University of Exeter
- Samantha M. Thomas🇺🇸National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases
- Nicholas F. McMahon🇦🇺The University of Queensland
- Anni Vanhatalo🇬🇧University of Exeter
- Alan N. Schechter🇺🇸National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases
- ANDREW MARK JONES🇬🇧 · autor de correspondenciaUniversity of Exeter
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate (NO3-) ingestion can be beneficial for health and exercise performance. Recently, based on animal and limited human studies, a skeletal muscle NO3- reservoir has been suggested to be important in whole body nitric oxide (NO) homeostasis. The purpose of this study was to determine the time course of changes in human skeletal muscle NO3- concentration ([NO3-]) following the ingestion of dietary NO3-. Sixteen participants were allocated to either an experimental group (NIT: n = 11) which consumed a bolus of ∼1300 mg (12.8 mmol) potassium nitrate (KNO3), or a placebo group (PLA: n = 5) which consumed a bolus of potassium chloride (KCl). Biological samples (muscle (vastus lateralis), blood, saliva and urine) were collected shortly before NIT or PLA ingestion and at intervals over the course of the subsequent 24 h. At baseline, no differences were observed for muscle [NO3-] and [NO2-] between NIT and PLA (P > 0.05). In PLA, there were no changes in muscle [NO3-] or [NO2-] over time. In NIT, muscle [NO3-] was significantly elevated above baseline (54 ± 29 nmol/g) at 0.5 h, reached a peak at 3 h (181 ± 128 nmol/g), and was not different to baseline from 9 h onwards (P > 0.05). Muscle [NO2-] did not change significantly over time. Following ingestion of a bolus of dietary NO3-, skeletal muscle [NO3-] increases rapidly, reaches a peak at ∼3 h and subsequently declines towards baseline values. Following dietary NO3- ingestion, human m. vastus lateralis [NO3-] expressed a slightly delayed pharmacokinetic profile compared to plasma [NO3-].
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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