Financiado en parte por Danone
Dietary cholesterol and egg intake are associated with the risk of gestational diabetes: a prospective study from Southwest China
Zhang Y, Lan X, Li F, Sun H, Zhang J, Li R, Gao Y, Dong H, Cai C, Zeng G
BMC pregnancy and childbirth · 9 citas
Etiquetas de revisión
Financiado por la industriaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Danone
Según 1 financiador declarado.
Publicación
- Publicado
- 2022-01-17 · BMC Pregnancy Childbirth · vol. 22 · número 1 · pág. 45
- Editorial
- BioMed Central
- Citado
- 11 citas · más que el 82% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gestational Diabetes Research and Management · Birth, Development, and Health · Pregnancy and preeclampsia studies
- Palabras clave
- Medicine, Gestational diabetes, Cholesterol, Quartile, Odds ratio, Pregnancy, Prospective cohort study, Diabetes mellitus, Gestation, Dietary Cholesterol, Population, Internal medicine, Endocrinology, Obstetrics, Confidence interval, Environmental health, Biology
- MeSH
- humans, diabetes, gestational, cholesterol, dietary, triglycerides, diet surveys, logistic models, odds ratio, prospective studies, pregnancy, eggs, adult, china, female, cholesterol, ldl, cholesterol, hdl, maternal nutritional physiological phenomena
10 autores
- Yiqi Zhang🇨🇳Sichuan University
- Xi Lan🇨🇳Sichuan University
- Fei Li🇨🇳Sichuan University
- Hong Sun🇨🇳Sichuan University
- Ju Zhang🇨🇳Chengdu Women's and Children's Central Hospital
- Run Li🇨🇳Chengdu Women's and Children's Central Hospital
- Yan Gao🇨🇳Chengdu Women's and Children's Central Hospital
- Hongli Dong🇨🇳Sichuan University
- Congjie Cai🇨🇳Sichuan University
- Guo Zeng🇨🇳 · autor de correspondenciaSichuan University; West China Hospital of Sichuan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
An increasing body of evidence suggests that cholesterol intake increases during pregnancy and may influence the risk of gestational diabetes mellitus (GDM). However, existing evidence remains controversial and limited. The present study aimed to determine the relation among dietary cholesterol, specifically egg consumption, in pregnant Chinese women and their risk of GDM.
Methods
A population-based study that included 1617 pregnant women was conducted in 2017. At baseline, dietary information was collected by 24-hour dietary recalls over three days. GDM was diagnosed by a 75 g 2-hr oral glucose tolerance test (OGTT) at 24-28 weeks of gestation. Logistic regression models were used to examine the associations of dietary cholesterol and egg intake with GDM. In addition, path analysis including cholesterol intake, plasma lipid profiles and GDM risk was conducted.
Results
The average total cholesterol intake was 340.8 mg/d, and cholesterol from eggs accounted for 59.2%. The odds ratio (OR) of GDM risk was 1.48 for the highest quartile of total cholesterol intake compared to the lowest quartile (95% CI 1.10-2.00; P trend = 0.015) after adjustment for potential risk factors for GDM. Moreover, cholesterol from eggs rather than from other foods was positively associated with incident GDM (OR=1.09, 95% CI 1.03-1.17). Each additional egg consumed per day was positively correlated with a higher risk of GDM (OR=1.32, 95% CI 1.11-1.58). Path analysis indicated that cholesterol intake not only increased the risk of GDM by elevating plasma total cholesterol (TC), but also increased the risk of GDM through other non hyperlipidemia pathways.
Conclusions
Maternal dietary cholesterol intake was significantly associated with incident GDM, and egg consumption was a major driver of the association in this population. More studies are needed to substantiate these findings and to explore the underlying mechanisms.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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