Whole Grain Consumption and Inflammatory Markers: A Systematic Literature Review of Randomized Control Trials
Milesi G, Rangan A, Grafenauer S
Nutrients · 41 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-01-16 · Nutrients · vol. 14 · número 2 · pág. 374
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 52 citas · más que el 88% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 62 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutrition and Health in Aging · Adipokines, Inflammation, and Metabolic Diseases · GDF15 and Related Biomarkers
- Palabras clave
- Medicine, Randomized controlled trial, Internal medicine, Systematic review, Overweight, Meta-analysis, Population, MEDLINE, CINAHL, Obesity, Psychological intervention, Environmental health, Biology
- MeSH
- humans, obesity, inflammation, tumor necrosis factor-alpha, c-reactive protein, inflammation mediators, interleukin-6, adult, aged, aged, 80 and over, middle aged, overweight, randomized controlled trials as topic, young adult, biomarkers, whole grains, bias
3 autores
- Genevieve Milesi🇦🇺The University of Sydney
- Anna Rangan🇦🇺The University of Sydney
- Sara Grafenauer🇦🇺 · autor de correspondenciaUNSW Sydney
Resumen
El texto original del estudio, en el idioma en que se publicó.
Whole grain foods are rich in nutrients, dietary fibre, a range of antioxidants, and phytochemicals, and may have potential to act in an anti-inflammatory manner, which could help impact chronic disease risk. This systematic literature review aimed to examine the specific effects of whole grains on selected inflammatory markers from human clinical trials in adults. As per the Preferred Reporting Items for Systematic Reviews (PRISMA) protocol, the online databases MEDLINE, Embase, Cochrane, CINAHL, and Scopus were searched from inception through to 31 August 2021. Randomized control trials (RCTs) ≥ 4 weeks in duration, reporting ≥1 of the following: C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor (TNF), were included. A total of 31 RCTs were included, of which 16 studies recruited overweight/obese individuals, 12 had pre-existing conditions, two were in a healthy population, and one study included participants with prostate cancer. Of these 31 RCTs, three included studies with two intervention arms. A total of 32 individual studies measured CRP (10/32 were significant), 18 individual studies measured IL-6 (2/18 were significant), and 13 individual studies measured TNF (5/13 were significant). Most often, the overweight/obese population and those with pre-existing conditions showed significant reductions in inflammatory markers, mainly CRP (34% of studies). Overall, consumption of whole grain foods had a significant effect in reducing at least one inflammatory marker as demonstrated in 12/31 RCTs.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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