A Randomized, Open-Label Study to Assess Efficacy of Weekly Assumption of Cholecalciferol versus Calcifediol in Older Patients with Hypovitaminosis D
Okoye C, Calsolaro V, Niccolai F, Calabrese AM, Franchi R, Rogani S, Coppini G, Morelli V, Caraccio N, Monzani F
Geriatrics (Basel, Switzerland) · 5 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-01-07 · Geriatrics (Basel) · vol. 7 · número 1 · pág. 13
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 10 citas · más que el 80% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Pharmacological Effects and Toxicity Studies
- Palabras clave
- Calcifediol, Cholecalciferol, Medicine, Vitamin D and neurology, Internal medicine, Hypovitaminosis, Quality of Life Research, Vitamin, vitamin D deficiency, Gastroenterology, Endocrinology, Pathology, Public health
10 autores
- Chukwuma Okoye🇮🇹University of Pisa
- Valeria Calsolaro🇮🇹University of Pisa
- Filippo Niccolai🇮🇹University of Pisa
- Alessia Maria Calabrese🇮🇹University of Pisa
- Riccardo Franchi🇮🇹University of Pisa
- Sara Rogani🇮🇹University of Pisa
- Giulia Coppini🇮🇹University of Pisa
- Virginia Morelli🇮🇹University of Pisa
- Nadia Caraccio🇮🇹University of Pisa
- Fabio Monzani🇮🇹 · autor de correspondenciaUniversity of Pisa
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of this single-center, open-label, randomized controlled study was to evaluate which formulation of vitamin D-between cholecalciferol and calcifediol-is most effective in the treatment of hypovitaminosis D in older adults. Demographic characteristics, clinical history, and comprehensive geriatric assessment were recorded at admission. Eligible patients were randomly assigned an equivalent vitamin D supplement, either with cholecalciferol or calcifediol, from the time of hospital admission to three months after discharge. Among the 140 older patients included (mean age 83 ± 6.6 years, 57.8% females), 69 received cholecalciferol and 71 received calcifediol. The mean plasma values of 25-hydroxyvitamin D3 (25OH-vitamin D3) found at the time of enrollment were 16.8 ± 9.9 ng/mL in patients receiving cholecalciferol and 18.8 ± 13.3 ng/mL in those treated with calcifediol (p = 0.31). At the three month follow-up, the mean concentration of 25OH-vitamin D3 was significantly higher in patients treated with calcifediol than in those receiving cholecalciferol (30.7 ± 8.4 vs. 45.4 ± 9.8 ng/mL, respectively; p < 0.001). Supplementation with either cholecalciferol or calcifediol effectively results in reaching the optimal circulating values of 25OH-vitamin D3 in older patients suffering from hypovitaminosis D. However, supplementation with calcifediol led to average circulating values of 25OH-vitamin D3 that were significantly higher (over 50%) than those obtained with cholecalciferol.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.