Dark Green Leafy Vegetable Intake, MTHFR Genotype, and Risk of Cutaneous Squamous Cell Carcinoma
Hughes MCB, Antonsson A, Rodriguez-Acevedo AJ, Liyanage UE, Green AC, van der Pols JC
Dermatology (Basel, Switzerland) · 4 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoFinanciación no declaradaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-01-01 · Dermatology · vol. 238 · número 4 · págs. 657–661
- Editorial
- Karger Publishers
- Citado
- 7 citas · más que el 76% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 16 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC
- Áreas de investigación
- Folate and B Vitamins Research · Skin Protection and Aging · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Methylenetetrahydrofolate reductase, Medicine, Relative risk, Genotype, Internal medicine, Confidence interval, Animal science, Skin cancer, Gastroenterology, Biology, Cancer, Genetics, Gene
- MeSH
- humans, vegetables, carcinoma, squamous cell, skin neoplasms, genetic predisposition to disease, folic acid, methylenetetrahydrofolate reductase (nadph2), risk factors, case-control studies, longitudinal studies, genotype, australia
6 autores
- Maria Celia B. Hughes🇦🇺QIMR Berghofer Medical Research Institute
- Annika Antonsson🇦🇺The University of Queensland; QIMR Berghofer Medical Research Institute
- Astrid J. Rodriguez‐Acevedo🇦🇺The University of Queensland
- Upekha E. Liyanage🇦🇺The University of Queensland; QIMR Berghofer Medical Research Institute
- Adèle C. Green🇦🇺🇬🇧QIMR Berghofer Medical Research Institute; Manchester Academic Health Science Centre; University of Manchester
- Jolieke C. van der Pols🇦🇺Queensland University of Technology; QIMR Berghofer Medical Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Evidence suggests that consumption of dark green leafy vegetables may influence the decrease in the risk of cutaneous squamous cell carcinoma (SCC). Dark green leafy vegetables contain folate as a main component among other nutrients; thus, we hypothesised that their possible observed protective effect on SCC, observed in previous studies, would be more evident in persons with specific genotypes related to folate metabolism.
Methods
Genotyping of methylenetetrahydrofolate reductase (MTHFR) gene variants rs1801133 (C677T) and rs1801131 (A1298C) was carried out for 1,128 participants in an Australian community-based longitudinal study of skin cancer. Dietary intakes were assessed through repeated Food Frequency Questionnaires (1992-1996), and all incident skin cancers were recorded in 1992-2007 and histologically confirmed. We assessed associations between intake of dark green leafy vegetables and SCC development in strata defined by genotype, by calculating relative risks (RRs) with 95% confidence intervals (CIs) using generalised linear models with negative binomial distribution and person-years of follow-up as offset.
Results
High versus low intake of dark green leafy vegetables was associated with a lower risk of SCC tumours in carriers of the C677T variant allele (RR = 0.42, 95% CI = 0.23-0.75), and within wild-type A1298C homozygotes (RR = 0.43, 95% CI = 0.22-0.85).
Conclusion
The protective effect of dark green leafy vegetables on cutaneous SCC may be genotype-dependent. Folate metabolism-related gene polymorphisms should be considered when assessing the relation of green leafy vegetables to cancer risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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