Associations Between Unprocessed Red Meat and Processed Meat With Risk of Recurrence and Mortality in Patients With Stage III Colon Cancer
Van Blarigan EL, Ou FS, Bainter TM, Fuchs CS, Niedzwiecki D, Zhang S, Saltz LB, Mayer RJ, Hantel A, Benson AB, Atienza D, Messino M, Kindler HL, Venook AP, Ogino S, Sanoff HK, Giovannucci EL, Ng K, Meyerhardt JA
JAMA network open · 9 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (UG1CA233327); National Cancer Institute (K07 CA197077); National Cancer Institute (R01CA118553); National Cancer Institute (U10 CA180821); National Cancer Institute (U10-CA180888); National Cancer Institute (U10CA180836); National Cancer Institute (UG1 CA233180); National Cancer Institute (U10 CA180867); National Cancer Institute (U10 CA180791); National Cancer Institute (R35CA197735); National Cancer Institute (UG1CA233290); National Cancer Institute (U10CA077651); National Cancer Institute (U10CA041287); National Cancer Institute (UG1 CA233373); National Cancer Institute (U10CA180820); National Cancer Institute (U10-CA180882); National Cancer Institute (U10 CA138561); National Cancer Institute (U10CA045808); National Cancer Institute (U10 CA032291); National Cancer Institute (UG1 CA233337); National Cancer Institute (UG1CA189858); National Cancer Institute (#P30-CA008748)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2022-02-22 · JAMA Netw Open · vol. 5 · número 2 · pág. e220145
- Editorial
- American Medical Association
- Citado
- 15 citas · más que el 89% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 22 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Colorectal Cancer Screening and Detection · Agriculture Sustainability and Environmental Impact
- Palabras clave
- Medicine, Red meat, Colorectal cancer, Cancer, Hazard ratio, Internal medicine, Prospective cohort study, Quartile, Surgery, Confidence interval, Pathology
- MeSH
- humans, colonic neoplasms, neoplasm recurrence, local, diet, proportional hazards models, prospective studies, aged, middle aged, female, male, red meat
19 autores
- Erin Lynn Van Blarigan🇺🇸 · autor de correspondenciaUniversity of California, San Francisco
- Fang‐Shu Ou🇺🇸Mayo Clinic
- Tiffany M. Bainter🇺🇸Mayo Clinic
- Charles S. Fuchs🇺🇸Yale Cancer Center
- Donna Niedzwiecki🇺🇸Duke University
- Sui Zhang🇺🇸Johns Hopkins University
- Leonard B. Saltz🇺🇸Memorial Sloan Kettering Cancer Center
- Robert J. Mayer🇺🇸Dana-Farber Cancer Institute
- Alexander Hantel
- Al B. Benson🇺🇸Northwestern University
- Daniel M. Atienza🇺🇸Virginia Oncology Associates
- Michael J. Messino🇺🇸Southeast Clinical Oncology Research Consortium; Mission Hospital
- Hedy Lee Kindler🇺🇸University of Chicago
- Alan Paul Venook🇺🇸University of California, San Francisco; UCSF Helen Diller Family Comprehensive Cancer Center
- Shuji Ogino🇺🇸Broad Institute; Brigham and Women's Hospital; Harvard University; Massachusetts Institute of Technology
- Hanna Kelly Sanoff🇺🇸University of North Carolina at Chapel Hill; UNC Lineberger Comprehensive Cancer Center
- Edward L. Giovannucci🇺🇸Brigham and Women's Hospital; Harvard University
- Kimmie Ng🇺🇸Dana-Farber Cancer Institute
- Jeffrey A. Meyerhardt🇺🇸Dana-Farber Cancer Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Importance
The American Cancer Society and American Institute for Cancer Research recommend that cancer survivors limit intake of red and processed meats. This recommendation is based on consistent associations between red and processed meat intake and cancer risk, particularly risk of colorectal cancer, but fewer data are available on red and processed meat intake after cancer diagnosis.
Objectives
To examine whether intake of unprocessed red meat or processed meat is associated with risk of cancer recurrence or mortality in patients with colon cancer.
Design, setting, and participants
This prospective cohort study used data from participants with stage III colon cancer enrolled in the Cancer and Leukemia Group B (CALGB 89803/Alliance) trial between 1999 and 2001. The clinical database for this analysis was frozen on November 9, 2009; the current data analyses were finalized in December 2021.
Exposures
Quartiles of unprocessed red meat and processed meat intake assessed using a validated food frequency questionnaire during and 6 months after chemotherapy.
Main outcomes and measures
Hazard ratios (HRs) and 95% CIs for risk of cancer recurrence or death and all-cause mortality.
Results
This study was conducted among 1011 patients with stage III colon cancer. The median (IQR) age at enrollment was 60 (51-69) years, 442 patients (44%) were women, and 899 patients (89%) were White. Over a median (IQR) follow-up period of 6.6 (1.9-7.5) years, we observed 305 deaths and 81 recurrences without death during follow-up (386 events combined). Intake of unprocessed red meat or processed meat after colon cancer diagnosis was not associated with risk of recurrence or mortality. The multivariable HRs comparing the highest vs lowest quartiles for cancer recurrence or death were 0.84 (95% CI, 0.58-1.23) for unprocessed red meat and 1.05 (95% CI, 0.75-1.47) for processed meat. For all-cause mortality, the corresponding HRs were 0.71 (95% CI, 0.47-1.07) for unprocessed red meat and 1.04 (95% CI, 0.72-1.51) for processed meat.
Conclusions and relevance
In this cohort study, postdiagnosis intake of unprocessed red meat or processed meat was not associated with risk of recurrence or death among patients with stage III colon cancer.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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