Randomized controlled trial for time-restricted eating in healthy volunteers without obesity
Xie Z, Sun Y, Ye Y, Hu D, Zhang H, He Z, Zhao H, Yang H, Mao Y
Nature communications · 226 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Chinese Academy of Medical Sciences
- Subvenciones
- Chinese Academy of Medical Sciences (CIFMS No.2016-I2M-1-001)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-02-22 · Nat Commun · vol. 13 · número 1 · pág. 1003
- Editorial
- Nature Portfolio
- Citado
- 278 citas · más que el 100% de estudios similares · 27.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 77 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Sleep and related disorders
- Palabras clave
- Randomized controlled trial, Obesity, Medicine, Time trial, Internal medicine
- MeSH
- humans, insulin resistance, obesity, glucose, fasting, healthy volunteers
9 autores
- Zhibo Xie🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yuning Sun🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yuqian Ye🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Dandan Hu🇨🇳Sun Yat-sen University; Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital; Sun Yat-sen University Cancer Center
- Hua Zhang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Zhangyuting He🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Haitao Zhao🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Huayu Yang🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yilei Mao🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the middle of the day) have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared. We conducted a five-week randomized trial to compare the effects of the two TRF regimens in healthy individuals without obesity (ChiCTR2000029797). The trial has completed. Ninety participants were randomized to eTRF (n=30), mTRF (n=30), or control groups (n=30) using a computer-based random-number generator. Eighty-two participants completed the entire five-week trial and were analyzed (28 in eTRF, 26 in mTRF, 28 in control groups). The primary outcome was the change in insulin resistance. Researchers who assessed the outcomes were blinded to group assignment, but participants and care givers were not. Here we show that eTRF was more effective than mTRF at improving insulin sensitivity. Furthermore, eTRF, but not mTRF, improved fasting glucose, reduced total body mass and adiposity, ameliorated inflammation, and increased gut microbial diversity. No serious adverse events were reported during the trial. In conclusion, eTRF showed greater benefits for insulin resistance and related metabolic parameters compared with mTRF. Clinical Trial Registration URL: http://www.chictr.org.cn/showproj.aspx?proj=49406 .
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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