Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
Nouri-Majd S, Salari-Moghaddam A, Aminianfar A, Larijani B, Esmaillzadeh A
Frontiers in nutrition · 28 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-02-07 · Front Nutr · vol. 9 · pág. 801722
- Editorial
- Frontiers Media
- Citado
- 49 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Prostate Cancer Diagnosis and Treatment · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Prostate cancer, Meta-analysis, Funnel plot, Medicine, Publication bias, Relative risk, Random effects model, Prospective cohort study, Prostate, Cancer, Oncology, Internal medicine, Confidence interval
5 autores
- Saeedeh Nouri-Majd🇮🇷Tehran University of Medical Sciences
- Asma Salari-Moghaddam🇮🇷Tehran University of Medical Sciences
- Azadeh Aminianfar🇮🇷Kashan University of Medical Sciences
- Bagher A. Larijani🇮🇷Obesity and Eating Habits Research Center; Tehran University of Medical Sciences
- Ahmad Esmaillzadeh🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences; Obesity and Eating Habits Research Center; Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Debate on the potential carcinogenic effects of meat intake is open and the relationship between meat consumption and risk of prostate cancer remains uncertain. This meta-analysis was conducted to summarize earlier prospective studies on the association of meat consumption with risk of prostate cancer.
Methods
Relevant studies were identified by exploring PubMed/Medline, Scopus, Web of Science, EMBASE, and Google Scholar databases up to December 2020. Fixed-effects and random-effects meta-analyses were used for pooling the relative risks (RRs). Heterogeneity across studies was evaluated using the Q-statistic and I-square (I 2). A funnel plot and Egger's test was used to detect publication bias. Linear and non-linear dose-response analyses were performed to estimate the dose-response relations between meat intake and risk of prostate cancer.
Results
Twenty-five prospective studies were included in this meta-analysis. Totally, 1,900,910 participants with 35,326 incident cases of prostate cancer were investigated. Pooling the eligible effect sizes, we observed that high consumption of processed meat might be associated with an increased risk of "total prostate cancer" (RR: 1.06; 95% CI: 1.01, 1.10; I 2 = 1.5%, P = 0.43) and "advanced prostate cancer" (1.17; 1.09, 1.26; I 2 = 58.8%, P = 0.01). However, the association between processed meat and "advanced prostate cancer" was not significant in the random-effects model: 1.12 (95% CI: 0.98, 1.29). A linear dose-response analysis indicated that an increment of 50 grams per day of processed meat intake might be related to a 4% greater risk of "total prostate cancer" (1.04; 1.00, 1.08; I 2 = 0.0%, P = 0.51). "Total meat intake" was marginally associated with all outcomes of prostate cancer risk (1.04; 1.01, 1.07; I 2 = 58.4%, P < 0.001).
Conclusions
This systematic review and meta-analysis of prospective studies indicated that increased consumption of "total meat" and "processed meat" might be associated with a higher risk of prostate cancer.
Systematic review registration
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=230824, identifier: CRD42021230824.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.