Cholecalciferol level and its impact on COVID-19 patients
Saeed MAM, Mohamed AH, Owaynat AH
The Egyptian journal of internal medicine · 3 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-02-21 · Egypt J Intern Med · vol. 34 · número 1 · pág. 23
- Editorial
- Springer Nature
- Citado
- 6 citas · más que el 69% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · COVID-19 Clinical Research Studies · Vitamin C and Antioxidants Research
- Palabras clave
- Cholecalciferol, Vitamin D and neurology, Medicine, vitamin D deficiency, Vitamin, Coronavirus disease 2019 (COVID-19), Internal medicine, Gastroenterology, Pediatrics, Disease, Infectious disease (medical specialty)
3 autores
- Mohammed Abdel Monem Saeed🇪🇬 · autor de correspondenciaHelwan University
- Alaa Hussein Mohamed🇪🇬Helwan University
- Ahmed Hassan Owaynat🇪🇬Helwan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Cholecalciferol is an important nutrient and essential to build body, maintain strong bones, and improves immunity.The main source for vitamin D is the body's skin which absorbs the sun's ultraviolet rays and convert them into vitamin D; at the same time, deficiency can occur or people may not get enough supplementation; this occurs mainly in old age, not taking healthy food, or have darker skin, and this deficient cases can raise the risk of severe COVID-19 if infected.Vitamin D boosts immunity and decreases inflammation. Poorer outcome of corona virus-disease (COVID-19) has been suggested to be due to vitamin D deficiency.We suggested to find the effect of cholecalciferol levels 25-hydroxy vitamin D (25 OHD) on the severity and mortality in patients suffering from COVID-19.
Methods
Our study is a prospective following of 414 patients admitted in Helwan University Hospitals in the period of June 2020 till October 2021 for severely symptomatic. COVID-19 patients with median of age 54.55 ± 14.27, with a definite range of APACHE II score ranging from 15 to 19 where we measured vitamin D3 level (cholecalciferol level), correlating the assay level to the inflammatory cytokine storm markers on admission, on the fifth day and after 10 days also the level of vitamin D3 was correlated to the length of stay mechanical ventilation days and mortality.
Results
Lower level of vitamin D3 on admission was strongly evident in patients with severely symptomatic and in mortality of COVID-19 patients 58.25 ± 24.59 nmol/L when compared with patients who survived 103.97 ± 36.14 nmol/L with P value 3 on admission with the level of the inflammatory cytokine storm markers on admission, on fifth day from admission and on the tenth day, it shows a strong inverse correlation between vitamin D3 level on admission and ferritin level on fifth day ρ-0.739 p value P value p value p value this also evident on the D-dimer level on the tenth day ρ-0.889 with p value P value P value 3 it shows a strong inverse correlation with a highly significant p value. ρ-0.887, P value p value 3 level (cholecalciferol) on admission with ρ-0.753, p P p value p P 3 to predict mortality (RR 0.865, 95% CI 0.828-0.896, P 3 < 60 nmol/L, regardless of other factors like age, gender, and presence of other co-morbidities.
Conclusion
Low level of cholecalciferol was strongly inversely correlated with cytokine storm markers and independent predictor of severity and mortality in COVID-19 patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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