Role of Magnesium Supplementation in Children with West Syndrome: A Randomized Controlled Clinical Trial
Yadav VK, Amrita A, Yadav S, Kumar R, Yadav KK
Iranian journal of child neurology · 3 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-01-01 · Iran J Child Neurol · vol. 16 · número 1 · págs. 65–75
- Editorial
- National Institutes of Health
- Citado
- 4 citas · más que el 54% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 22 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Epilepsy research and treatment · Neuroscience and Neuropharmacology Research
- Palabras clave
- Hypsarrhythmia, Medicine, Randomized controlled trial, Pediatrics, Epilepsy, Epileptic spasms, West Syndrome, Epilepsy syndromes, Clinical trial, Intervention (counseling), Encephalopathy, Internal medicine, Psychiatry
5 autores
- Vijay Kumar Yadav
- Amrita Amrita
- Sunita Kumari Yadav🇮🇳Ambedkar University Delhi
- Rajeev Kumar🇮🇳Narayana Health
- Krishna Kumar Yadav🇮🇳Dr. Ram Manohar Lohia Institute of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
West syndrome is a severe epileptic encephalopathy of young age. It is characterized by a clinico-electrical triad of infantile epileptic spasms, regression or arrest of psychomotor development, and hypsarrhythmia. In the last two decades, the large progress in the development of newer antiepileptic drugs has allowed us to have a vast choice of treatment options to control spasms, although they often fail to do so. Thus, there is a need to explore other treatment options.
Materials & methods
Subjects in this open-labelled randomized control trial were included newly diagnosed children of age between 3 months and 5 years of both genders. A total of 52 children were recruited and randomized into two groups: an intervention group (n=30) and a non-intervention group (n=22). Magnesium sulphate was provided for the intervention group but not for the non-intervention one. Both groups received the rest of the treatments, including adrenocorticotropic hormone and antiepileptic drugs. The follow-up period was three months, at the end of which a per-protocol analysis was performed.
Results
There was no significant difference in seizure control and neurodevelopmental outcome between both groups, but electroencephalogram significantly improved in the intervention group compared to the control. Also, the clinical response was better in patients with normal initial serum magnesium levels in the intervention group (p=0.003) than in other patients.
Conclusion
Magnesium supplementation may be helpful in children with West syndrome.
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