Association of Serum 25-Hydroxyvitamin D With Cardiovascular Outcomes and All-Cause Mortality in Individuals With Prediabetes and Diabetes: Results From the UK Biobank Prospective Cohort Study
Zhang P, Guo D, Xu B, Huang C, Yang S, Wang W, Liu W, Deng Y, Li K, Liu D, Lin J, Wei X, Huang Y, Zhang H
Diabetes care · 63 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Southern Medical University
- Universidad u hospital
- Nanfang Hospital
- Subvenciones
- Southern Medical University (LC2019ZD010); National Natural Science Foundation of China (81970736); Southern Medical University (2018YFA0800404); National Natural Science Foundation of China (LC2019ZD010); National Natural Science Foundation of China (2019CR022); Southern Medical University (2019CR022); Southern Medical University (81970736)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2022-02-28 · Diabetes Care · vol. 45 · número 5 · págs. 1219–1229
- Editorial
- American Diabetes Association
- Citado
- 77 citas · más que el 99% de estudios similares · 8.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista híbrida) · OTHER-OA
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Estrogen and related hormone effects
- Palabras clave
- Medicine, Prediabetes, Hazard ratio, Internal medicine, Diabetes mellitus, Proportional hazards model, Prospective cohort study, Cohort study, Population, Cohort, Type 2 diabetes, Endocrinology, Confidence interval
- MeSH
- humans, cardiovascular diseases, coronary disease, diabetes mellitus, prediabetic state, vitamin d, risk factors, cohort studies, prospective studies, adult, biological specimen banks, heart failure, stroke, united kingdom
14 autores
- Peizhen Zhang🇨🇳 · autor de correspondenciaKey Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Dan Guo🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Bingyan Xu🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Chensihan Huang🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Shunyu Yang🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Weiwei Wang🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Wenhui Liu🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Yajuan Deng🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Kangli Li🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Deying Liu🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Jiayang Lin🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Xueyun Wei🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Yan Huang🇨🇳Key Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
- Huijie Zhang🇨🇳 · autor de correspondenciaKey Laboratory of Guangdong Province; Nanfang Hospital; Southern Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the associations of circulating 25-hydroxyvitamin D (25[OH]D) concentrations with cardiovascular disease (CVD) and all-cause mortality in individuals with prediabetes and diabetes from the large population-based UK Biobank cohort study.
Research design and methods
A total of 67,789 individuals diagnosed with prediabetes and 24,311 with diabetes who had no CVD or cancer at baseline were included in the current study. Serum 25(OH)D concentrations were measured at baseline. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% CIs for cardiovascular outcomes and mortality after 10-14 years.
Results
After multivariable adjustment, higher serum 25(OH)D levels were significantly and nonlinearly associated with lower risk of cardiovascular outcomes and all-cause mortality among participants with prediabetes and diabetes (all P nonlinearity < 0.05). Compared with those in the lowest category of 25(OH)D levels (<25 nmol/L), participants with prediabetes in the highest category of 25(OH)D levels (≥75 nmol/L) had a significant association with lower risk of cardiovascular events (HR 0.78; 95% CI 0.71-0.86), coronary heart disease (CHD) (HR 0.79; 95% CI 0.71-0.89), heart failure (HR 0.66; 95% CI 0.54-0.81), stroke (HR 0.75; 95% CI 0.61-0.93), CVD mortality (HR 0.43; 95% CI 0.32-0.59), and all-cause mortality (HR 0.66; 95% CI 0.58-0.75). Likewise, these associations with cardiovascular events, CHD, heart failure, CVD mortality, and all-cause mortality were observed among participants with diabetes, except for stroke.
Conclusions
These findings highlight the importance of monitoring and correcting vitamin D deficiency in the prevention of CVD and mortality among adults with prediabetes and diabetes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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