Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts
Paluch AE, Bajpai S, Bassett DR, Carnethon MR, Ekelund U, Evenson KR, Galuska DA, Jefferis BJ, Kraus WE, Lee IM, Matthews CE, Omura JD, Patel AV, Pieper CF, Rees-Punia E, Dallmeier D, Klenk J, Whincup PH, Dooley EE, Pettee Gabriel K, Palta P, Pompeii LA, Chernofsky A, Larson MG, Vasan RS, Spartano N, Ballin M, Nordström P, Nordström A, Anderssen SA, Hansen BH, Cochrane JA, Dwyer T, Wang J, Ferrucci L, Liu F, Schrack J, Urbanek J, Saint-Maurice PF, Yamamoto N, Yoshitake Y, Newton RL, Yang S, Shiroma EJ, Fulton JE, Steps for Health Collaborative
The Lancet. Public health · 435 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Transportation
- Organización sin fines de lucro
- Robert Wood Johnson Foundation
- Organización sin fines de lucro
- American College of Sports Medicine
- Gobierno
- North Carolina Department of Transportation
- Organización sin fines de lucro
- British Heart Foundation
- Gobierno
- Deutsche Forschungsgemeinschaft
- Gobierno
- National Institutes of Health
- Gobierno
- Centers for Disease Control and Prevention
- Gobierno
- National Institute on Aging
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- Intramural NIH HHS
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIGMS NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Institute of General Medical Sciences (U54‐ GM104940); National Cancer Institute (R01CA227122); National Heart, Lung, and Blood Institute (R01HL136266); National Institutes of Health (Z99 AG999999); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-072476)
Según 18 financiadores declarados.
Publicación
- Publicado
- 2022-03-01 · Lancet Public Health · vol. 7 · número 3 · págs. e219–e228
- Editorial
- Elsevier BV
- Citado
- 602 citas · más que el 100% de estudios similares · 20.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Physical Activity and Health · Cardiovascular and exercise physiology · Urban Transport and Accessibility
- Palabras clave
- daily step count, stepping rate, all-cause mortality, physical activity, dose-response relationship, adults, older adults, mortality risk, physical activity guidelines, cohort studies, restricted cubic splines, publication bias, risk of bias assessment, subgroup analysis, sex differences, age differences, country differences
- MeSH
- humans, exercise, walking, proportional hazards models, adolescent, adult, aged, middle aged
45 autores
- Amanda E. Paluch🇺🇸 · autor de correspondenciaUniversity of Massachusetts Amherst
- Shivangi Bajpai🇺🇸University of Massachusetts Amherst
- David R. Bassett🇺🇸University of Tennessee at Knoxville
- Mercedes R. Carnethon🇺🇸Northwestern University
- Ulf Ekelund🇳🇴Norwegian Institute of Public Health; Norwegian School of Sport Sciences
- Kelly R. Evenson🇺🇸University of North Carolina at Chapel Hill
- Deborah A. Galuska🇺🇸Centers for Disease Control and Prevention; National Center for Chronic Disease Prevention and Health Promotion
- Barbara J.M.H. Jefferis🇬🇧University College London
- William E. Kraus🇺🇸Duke University
- I‐Min Lee🇺🇸Brigham and Women's Hospital; Harvard University
- Charles Edwards MatthewsDivision of Cancer Epidemiology and Genetics
- John D. Omura🇺🇸Centers for Disease Control and Prevention; National Center for Chronic Disease Prevention and Health Promotion
- Alpa V. Patel🇺🇸American Cancer Society
- Carl F. Pieper🇺🇸Duke Medical Center
- Erika Rees‐Punia🇺🇸American Cancer Society
- Dhayana Dallmeier🇺🇸🇩🇪Boston University; Agaplesion Bethesda Klinik
- Jochen Klenk🇩🇪Universität Ulm; Robert Bosch Hospital
- Peter H. Whincup🇬🇧University of London; St George's, University of London
- Erin E. Dooley🇺🇸University of Alabama at Birmingham
- Kelley Pettee Gabriel🇺🇸University of Alabama at Birmingham
- Priya Palta🇺🇸Columbia University Irving Medical Center
- Lisa A. Pompeii🇺🇸Baylor College of Medicine
- Ariel Chernofsky🇺🇸Boston University
- Martin G. Larson🇺🇸Boston University
- Ramachandran Srini Vasan🇺🇸Boston University
- Nicole L. Spartano🇺🇸Boston University
- Marcel Ballin🇸🇪Umeå University
- Peter Nordström🇸🇪Umeå University
- Anna Nordström🇳🇴🇸🇪UiT The Arctic University of Norway; Umeå University
- Sigmund A. Anderssen🇳🇴Norwegian Institute of Public Health; Norwegian School of Sport Sciences
- Bjørge Herman Hansen🇳🇴Norwegian Institute of Public Health; University of Agder; Norwegian School of Sport Sciences
- Jennifer Cochrane🇦🇺University of Tasmania; Menzies Institute for Medical Research
- Terence Dwyer🇦🇺🇬🇧University of Tasmania; University of Oxford; Murdoch Children's Research Institute; Menzies Institute for Medical Research
- Jing Wang🇦🇺Murdoch Children's Research Institute
- Luigi Ferrucci🇺🇸National Institute on Aging
- Fangyu Liu🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Jennifer A. Schrack🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Jacek K. Urbanek🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Pedro F. Saint‐MauriceDivision of Cancer Epidemiology and Genetics
- Naofumi Yamamoto🇯🇵Ehime University
- Yutaka YOSHITAKE🇯🇵Meio University
- Robert L. Newton🇺🇸Pennington Biomedical Research Center
- Shengping Yang🇺🇸Pennington Biomedical Research Center
- Eric J. Shiroma🇺🇸National Institute on Aging
- Janet Elizabeth Fulton🇺🇸Centers for Disease Control and Prevention; National Center for Chronic Disease Prevention and Health Promotion
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although 10 000 steps per day is widely promoted to have health benefits, there is little evidence to support this recommendation. We aimed to determine the association between number of steps per day and stepping rate with all-cause mortality.
Methods
In this meta-analysis, we identified studies investigating the effect of daily step count on all-cause mortality in adults (aged ≥18 years), via a previously published systematic review and expert knowledge of the field. We asked participating study investigators to process their participant-level data following a standardised protocol. The primary outcome was all-cause mortality collected from death certificates and country registries. We analysed the dose-response association of steps per day and stepping rate with all-cause mortality. We did Cox proportional hazards regression analyses using study-specific quartiles of steps per day and calculated hazard ratios (HRs) with inverse-variance weighted random effects models.
Findings
We identified 15 studies, of which seven were published and eight were unpublished, with study start dates between 1999 and 2018. The total sample included 47 471 adults, among whom there were 3013 deaths (10·1 per 1000 participant-years) over a median follow-up of 7·1 years ([IQR 4·3-9·9]; total sum of follow-up across studies was 297 837 person-years). Quartile median steps per day were 3553 for quartile 1, 5801 for quartile 2, 7842 for quartile 3, and 10 901 for quartile 4. Compared with the lowest quartile, the adjusted HR for all-cause mortality was 0·60 (95% CI 0·51-0·71) for quartile 2, 0·55 (0·49-0·62) for quartile 3, and 0·47 (0·39-0·57) for quartile 4. Restricted cubic splines showed progressively decreasing risk of mortality among adults aged 60 years and older with increasing number of steps per day until 6000-8000 steps per day and among adults younger than 60 years until 8000-10 000 steps per day. Adjusting for number of steps per day, comparing quartile 1 with quartile 4, the association between higher stepping rates and mortality was attenuated but remained significant for a peak of 30 min (HR 0·67 [95% CI 0·56-0·83]) and a peak of 60 min (0·67 [0·50-0·90]), but not significant for time (min per day) spent walking at 40 steps per min or faster (1·12 [0·96-1·32]) and 100 steps per min or faster (0·86 [0·58-1·28]).
Interpretation
Taking more steps per day was associated with a progressively lower risk of all-cause mortality, up to a level that varied by age. The findings from this meta-analysis can be used to inform step guidelines for public health promotion of physical activity.
Funding
US Centers for Disease Control and Prevention.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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