Effect of vitamin D monotherapy on indices of sarcopenia in community-dwelling older adults: a systematic review and meta-analysis
Prokopidis K, Giannos P, Katsikas Triantafyllidis K, Kechagias KS, Mesinovic J, Witard OC, Scott D
Journal of cachexia, sarcopenia and muscle · 104 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-03-08 · J Cachexia Sarcopenia Muscle · vol. 13 · número 3 · págs. 1642–1652
- Editorial
- Springer Science+Business Media
- Citado
- 135 citas · más que el 97% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 79 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutrition and Health in Aging · Vitamin D Research Studies · Frailty in Older Adults
- Palabras clave
- vitamin D supplementation, sarcopenia, community-dwelling older adults, grip strength, physical performance, appendicular lean mass, muscle strength, Short Physical Performance Battery, Timed Up and Go test, dietary intervention, monotherapy, frailty risk, fall risk, mortality risk, cardiovascular risk, cancer risk, diabetes risk
- MeSH
- humans, vitamins, vitamin d, dietary supplements, aged, sarcopenia, independent living
7 autores
- Konstantinos Prokopidis🇬🇧 · autor de correspondenciaUniversity of Liverpool
- Panagiotis Giannos🇬🇧Imperial College London
- Konstantinos Katsikas Triantafyllidis🇬🇧Musgrove Park Hospital; Taunton & Somerset NHS Foundation Trust; Somerset NHS Foundation Trust
- Konstantinos S. Kechagias🇬🇧Imperial College London
- Jakub Mesinovic🇦🇺Deakin University; Monash Health; Monash University
- Oliver C. Witard🇬🇧King's College London
- David S. Scott🇦🇺Deakin University; Monash Health; Monash University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D supplementation is proposed as a potentially effective nutritional intervention to mitigate the risk of sarcopenia. The aim of this systematic review and meta-analysis was to investigate the impact of vitamin D supplementation monotherapy on indices of sarcopenia in community-dwelling older adults.
Methods
A comprehensive search of the literature was conducted in PubMed, Web of Science, Scopus, and Cochrane Library. Eligible randomized controlled trials (RCTs) compared the effect of vitamin D supplementation (as monotherapy) with placebo on indices of sarcopenia in older (>50 years) adults. Using the random effects inverse-variance model, we calculated the mean difference (MD) in handgrip strength (HGS), short physical performance battery (SPPB), timed up and go (TUG), and appendicular lean mass (ALM) between groups. We also calculated the standardized mean difference (SMD) in general muscle strength and general physical performance (composite plot of all muscle strength and physical performance outcomes, respectively) between groups.
Results
Ten RCTs were included in the meta-analysis. A significant decrease in SPPB scores was observed with vitamin D supplementation compared with placebo (MD: -0.23; 95% CI -0.40 to -0.06; I2 = 0%; P = 0.007). Vitamin D supplementation conferred no effect on HGS (MD: -0.07 kg; 95% CI -0.70 to 0.55; I2 = 51%, P = 0.82), TUG (MD: 0.07 s; 95% CI -0.08 to 0.22; I2 = 0%, P = 0.35), ALM (MD: 0.06 kg/m2 ; 95% CI: -0.32 to 0.44; I2 = 73%, P = 0.77), general muscle strength (SMD: -0.01; 95% CI -0.17 to 0.15; I2 = 42%, P = 0.90), or general physical performance (SMD: -0.02; 95% CI -0.23 to 0.18; I2 = 71%, P = 0.83).
Conclusions
Vitamin D supplementation did not improve any sarcopenia indices in community-dwelling older adults and may compromise some aspects of physical performance. Future studies are warranted to investigate the impact of vitamin D supplementation on individual indices of SPPB, including mobility and balance, in older adults.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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