Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk
Wang F, Chandler PD, Zeleznik OA, Wu K, Wu Y, Yin K, Song R, Avila-Pacheco J, Clish CB, Meyerhardt JA, Zhang X, Song M, Ogino S, Lee IM, Eliassen AH, Liang L, Smith-Warner SA, Willett WC, Giovannucci EL
Nutrients · 17 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de casos y controles (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIH HHS
- Gobierno
- NCI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Cancer Institute (P01 CA087969); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK120870); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-119268); National Institutes of Health (U01-CA167552); National Institutes of Health (R01-CA67262); National Institutes of Health (R01 CA49449); National Institutes of Health (P01 CA 87969); National Institutes of Health (U01-CA176726); National Institutes of Health (R01DK120870); National Institutes of Health (UM1‐CA‐186107)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2022-02-25 · Nutrients · vol. 14 · número 5 · pág. 978
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 22 citas · más que el 93% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Metabolomics and Mass Spectrometry Studies · Fatty Acid Research and Health
- Palabras clave
- Metabolite, Red meat, Medicine, White meat, Logistic regression, Colorectal cancer, Food group, Food science, Internal medicine, Environmental health, Physiology, Biology, Cancer, Pathology
- MeSH
- animals, poultry, colorectal neoplasms, logistic models, follow-up studies, female, red meat
19 autores
- Fenglei Wang🇺🇸Harvard University
- Paulette D. Chandler🇺🇸Brigham and Women's Hospital; Harvard University
- Oana Alina Zeleznik🇺🇸Brigham and Women's Hospital; Harvard University
- Kana Wu🇺🇸Harvard University
- You Wu🇺🇸Harvard University
- Kanhua Yin🇺🇸Harvard University
- Rui Song🇺🇸Harvard University
- Julián Ávila-Pacheco🇺🇸Broad Institute
- Clary B. Clish🇺🇸Broad Institute
- Jeffrey A. Meyerhardt🇺🇸Harvard University; Dana-Farber Cancer Institute
- Xuehong Zhang🇺🇸Brigham and Women's Hospital; Harvard University
- Mingyang Song🇺🇸Harvard University; Massachusetts General Hospital
- Shuji Ogino🇺🇸Broad Institute; Brigham and Women's Hospital; Harvard University; Dana-Farber/Harvard Cancer Center
- I‐Min Lee🇺🇸Brigham and Women's Hospital; Harvard University
- A. Heather Eliassen🇺🇸Brigham and Women's Hospital; Harvard University
- Liming Liang🇺🇸Harvard University
- Stephanie A. Smith‐Warner🇺🇸Harvard University
- Walter Churchill Willett🇺🇸Brigham and Women's Hospital; Harvard University
- Edward L. Giovannucci🇺🇸 · autor de correspondenciaHarvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Red and processed meat consumption has been consistently associated with increased risk of colorectal cancer (CRC), but the association for fish intake is unclear. Evidence using objective dietary assessment approaches to evaluate these associations is sparse.
Objectives
We aim to investigate the plasma metabolite profiles related to red meat, poultry, and fish consumption and examine their associations with CRC risk.
Methods
We measured plasma metabolites among 5269 participants from the Nurses' Health Study (NHS), NHSII, and Health Professionals Follow-Up study (HPFS). We calculated partial Spearman correlations between each metabolite and self-reported intake of seven red meat, poultry, and fish groups. Metabolite profile scores correlated to self-reported dietary intakes were developed using elastic net regression. Associations between self-reported intakes, metabolite profile scores, and subsequent CRC risk were further evaluated using conditional logistic regression among 559 matched (1:1) case-control pairs in NHS/HPFS and replicated among 266 pairs in Women's Health Study.
Results
Plasma metabolites, especially highly unsaturated lipids, were differentially associated with red meat and fish groups. Metabolite profile scores for each food group were significantly correlated with the corresponding self-reported dietary intake. A higher dietary intake of processed red meat was associated with a higher risk of CRC (pooled OR per 1 SD, 1.15; 95% CI: 1.03, 1.29). In contrast, higher metabolite profile scores for all fish groups, not dietary intakes, were consistently associated with a lower CRC risk: the pooled OR per 1 SD was 0.86 (95% CI: 0.78, 0.96) for total fish, 0.86 (95% CI: 0.77, 0.96) for dark meat fish, and 0.87 (95% CI: 0.78, 0.97) for canned tuna fish. No significant associations were found for other food groups.
Conclusions
Red meat and fish intake exhibited systematically different plasma metabolite profiles. Plasma metabolite profile of fish intake was inversely associated with CRC risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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