Association between Dietary Nitrate, Nitrite Intake, and Site-Specific Cancer Risk: A Systematic Review and Meta-Analysis
Said Abasse K, Essien EE, Abbas M, Yu X, Xie W, Sun J, Akter L, Cote A
Nutrients · 54 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Riphah International University
- Subvenciones
- Riphah International University (ORIC-21-22/FPS-51)
Según 1 financiador declarado.
Publicación
- Publicado
- 2022-02-04 · Nutrients · vol. 14 · número 3 · pág. 666
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 98 citas · más que el 95% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 83 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Nutritional Studies and Diet · Potato Plant Research
- Palabras clave
- Nitrite, Meta-analysis, Nitrate, Medicine, Environmental health, Dietary Nitrate, Cancer, Food science, Internal medicine, Biology, Ecology
- MeSH
- humans, glioma, nitrates, nitrites, diet, risk
8 autores
- Kassim Said Abasse🇨🇦Université Laval
- Eno E. Essien🇨🇳Southeast University
- Muhammad Abbas🇵🇰 · autor de correspondenciaRiphah International University
- Xiaojin Yu🇨🇳 · autor de correspondenciaSoutheast University
- Weihua Xie🇨🇳Southeast University
- Jinfang Sun🇨🇳Southeast University
- Laboni Akter🇧🇩Institute of Epidemiology, Disease Control and Research
- André C. Côté🇨🇦 · autor de correspondenciaUniversité Laval
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
People consume nitrates, nitrites, nitrosamines, and NOCs compounds primarily through processed food. Many studies have yielded inconclusive results regarding the association between cancer and dietary intakes of nitrates and nitrites. This study aimed to quantify these associations across the reported literature thus far.
Methods
We performed a systematic review following PRISMA and MOOSE guidelines. A literature search was performed using Web of Science, Embase, PubMed, the Cochrane library, and google scholar up to January 2020. STATA version 12.0 was used to conduct meta-regression and a two-stage meta-analysis.
Results
A total of 41 articles with 13 different cancer sites were used for analysis. Of these 13 cancer types/sites, meta-regression analysis showed that bladder and stomach cancer risk was greater, and that pancreatic cancer risk was lower with increasing nitrite intakes. Kidney and bladder cancer risk were both lower with increasing nitrate intakes. When comparing highest to lowest (reference) categories of intake, meta-analysis of studies showed that high nitrate intake was associated with an increased risk of thyroid cancer (OR = 1.40, 95% CI: 1.02, 1.77). When pooling all intake categories and comparing against the lowest (reference) category, higher nitrite intake was associated with an increased risk of glioma (OR = 1.12, 95% CI: 1.03, 1.22). No other associations between cancer risk and dietary intakes of nitrates or nitrites were observed.
Conclusion
This study showed varied associations between site-specific cancer risks and dietary intakes of nitrate and nitrite. Glioma, bladder, and stomach cancer risks were higher and pancreatic cancer risk was lower with higher nitrite intakes, and thyroid cancer risk was higher and kidney cancer risk lower with higher nitrate intakes. These data suggest type- and site-specific effects of cancer risk, including protective effects, from dietary intakes of nitrate and nitrite.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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