5-Heptadecylresorcinol Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice by Modulating SIRT3 Signaling: The Possible Beneficial Effects of Whole Grain Consumption
Hao Y, Yang Z, Li Q, Wang Z, Liu J, Wang J
Molecular nutrition & food research · 8 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Beijing Municipal Commission of Education
- Subvenciones
- Beijing Municipal Commission of Education (KM202110011004); National Natural Science Foundation of China (32172207)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2022-03-17 · Mol Nutr Food Res · vol. 66 · número 9 · pág. e2101114
- Editorial
- Wiley
- Citado
- 13 citas · más que el 78% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Food composition and properties · Cardiovascular Disease and Adiposity · Phytochemicals and Antioxidant Activities
- Palabras clave
- Apolipoprotein E, Triglyceride, Apolipoprotein B, Apoptosis, Internal medicine, Endocrinology, Cholesterol, Western blot, Medicine, Pharmacology, Chemistry, Biochemistry, Disease
- MeSH
- animals, mice, inbred c57bl, mice, knockout, humans, mice, resorcinols, apolipoproteins e, signal transduction, atherosclerosis, sirtuin 3, plaque, atherosclerotic, human umbilical vein endothelial cells, whole grains
6 autores
- Yiming Hao🇨🇳Beijing Technology and Business University
- Zihui Yang🇨🇳Beijing Technology and Business University
- Qing Li🇨🇳Beijing Technology and Business University
- Ziyuan Wang🇨🇳Beijing Technology and Business University
- Jie Liu🇨🇳 · autor de correspondenciaBeijing Technology and Business University
- Jing Wang🇨🇳 · autor de correspondenciaBeijing Technology and Business University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
Whole grain consumption has been proven to be inversely associated with the risk of cardiovascular diseases. As a biomarker for whole grain dietary intake, 5-heptadecylresorcinol (AR-C17) has attracted increased attention due to its potential health-improving activity. However, the beneficial effect of AR-C17 on atherosclerosis prevention and the underlying mechanism remain unclear.
Methods and results
High-fat diet fed apolipoprotein E-deficient (ApoE-/- ) mice are administrated with or without AR-C17 (30 and 150 mg kg-1 ) for 16 weeks. Histological staining is performed for plaque analysis. Immunofluorescence, western blot, and seahorse cell analysis are carried out to investigate the action of mechanism of AR-C17. The results indicate that AR-C17 supplementation lowered serum total cholesterol, triglyceride, VLDL-C, and LDL-C levels. Moreover, the atherosclerotic plaques in the aortic root region of mice heart are significantly reduced by AR-C17 intervention compared with ApoE-/- control group. In addition, AR-C17 treatment alleviates endothelial cell damage and apoptosis by improving mitochondrial function via sirtuin3 signaling pathway both in ApoE-/- mice and oxidized-LDL-treated human umbilical vein endothelial cells.
Conclusion
AR-C17 may be applied as a promising grain-based dietary bioactive ingredient for atherosclerosis prevention. Meanwhile, as a mitochondrial protective agent, it can offer support for the suggested health claim of whole grain diet.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.