Impact of walnut consumption on cardio metabolic and anthropometric parameters in metabolic syndrome patients: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials
Arabi SM, Bahrami LS, Milkarizi N, Nematy M, Kalmykov V, Sahebkar A
Pharmacological research · 15 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Russian Science Foundation
- Subvenciones
- Russian Science Foundation (20-15-00337)
Según 1 financiador declarado.
Publicación
- Publicado
- 2022-03-23 · Pharmacol Res · vol. 178 · pág. 106190
- Editorial
- Elsevier BV
- Citado
- 19 citas · más que el 67% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 72 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- walnut consumption, metabolic syndrome, cardiometabolic risk factors, triglycerides, lipid profile, glucose homeostasis, insulin, HbA1c, C-reactive protein, anthropometric indices, waist circumference, body mass index, dose-response relationship, HDL cholesterol
- MeSH
- humans, juglans, cardiovascular diseases, body weight, insulin, glucose, blood glucose, triglycerides, c-reactive protein, adult, cholesterol, ldl, cholesterol, hdl, randomized controlled trials as topic, metabolic syndrome, glycated hemoglobin
6 autores
- Seyyed Mostafa Arabi🇮🇷University of Neyshabur; Mashhad University of Medical Sciences; Neyshabur University of Medical Sciences
- Leila Sadat Bahrami🇮🇷Mashhad University of Medical Sciences
- Narges Milkarizi🇮🇷Mashhad University of Medical Sciences
- Mohsen Nematy🇮🇷Mashhad University of Medical Sciences
- Vladislav A. Kalmykov🇷🇺Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences; Research Institute of Human Morphology
- Amirhossein Sahebkar🇮🇷🇦🇺 · autor de correspondenciaMashhad University of Medical Sciences; The University of Western Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
In recent years, the effect of walnut consumption on various components of metabolic syndrome (Mets) in different populations has been investigated. However, the findings on the alterations of cardiometabolic and anthropometric indices following walnut consumption in adults with Mets have not been fully conclusive.
Methods
The current study of eight randomized controlled trials (RCTs) examined the effects of walnut consumption on glucose homeostasis factors (fasting plasma glucose (FPG), insulin, hemoglobin A1C (HbA1c)), lipid profile (triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c)), high sensitivity C-reactive protein (hs-CRP) concentrations and anthropometric indices (body weight (BW), body mass index (BMI), and waist circumference (WC)) in trials of 549 participants. A systematic search was conducted in online databases including MEDLINE, Scopus, and Clarivate Analytics Web of Science uses related keywords to detect eligible studies until December 2021. To calculate the weighted mean difference (WMD) and 95% confidence intervals (CIs), a random-effects model was used.
Results
Results from the pooled analysis showed that serum TG concentration was significantly reduced (WMD, - 0.1 mmol/L; 95%CI (- 0.3 to - 0.02); p = 0.02; I2 = 38.6%; p = 0.10), although other lipid profile components (TC, LDL-c, and HDL-c), glucose homeostasis markers (FPG, insulin, and HbA1c), hs-CRP levels, anthropometric indices (BW, BMI, and WC) and blood pressure (SBP and DBP) were not influenced by walnut consumption. A significant dose-response association was detected between the dose of walnut intake and serum concentrations of FPG (Pnon-linearity dose-response non-linearity = 0.01, Pdose-response = 0.006).
Conclusions
Walnut consumption reduces serum TG levels in individuals with metabolic syndrome, but it cannot affect other cardiometabolic indices. Future well-designed and large RCTs are required to clarify further beneficial effects of walnut consumption on the cardiometabolic profile.
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