Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality: Systematic Review and Updated Meta-Analysis
Zhao B, Zhao B, Gan L, Graubard BI, Männistö S, Albanes D, Huang J
Circulation · 63 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- Intramural NIH HHS
- Subvenciones
- National Institutes of Health (Z01 SC000100)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2022-04-01 · Circulation · vol. 145 · número 20 · págs. 1506–1520
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 83 citas · más que el 97% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress · Cholesterol and Lipid Metabolism
- Palabras clave
- Medicine, Hazard ratio, Proportional hazards model, Cohort study, Cholesterol, Cohort, Internal medicine, Meta-analysis, Confidence interval
- MeSH
- humans, cardiovascular diseases, cholesterol, dietary, cause of death, risk factors, prospective studies, eggs, male
6 autores
- Bin Zhao🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Lu Gan🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Barry I. Graubard🇺🇸Department of Health and Human Services
- Satu Männistö🇫🇮Finnish Institute for Health and Welfare
- Demetrius Albanes🇺🇸Department of Health and Human Services
- Jiaqi Huang🇨🇳🇺🇸Central South University; Second Xiangya Hospital of Central South University; Department of Health and Human Services
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Despite substantial research highlighting the importance of exogenous dietary cholesterol intake and endogenous serum cholesterol level in human health, a thorough evaluation of the associations is lacking. Our study objective was to examine overall and cause-specific mortality in relation to dietary and serum cholesterol, as well as egg consumption, and conduct an updated meta-regression analysis of cohort studies.
Methods
We conducted a prospective analysis of 27 078 men in the ATBC Study (Alpha-Tocopherol, Beta-Carotene Cancer Prevention). Multivariable-controlled cause-specific Cox proportional hazards regression models were used to calculate hazard ratios and 31-year absolute mortality risk differences. A systematic review and meta-analysis of cohort studies was also performed (PROSPERO [URL: https://www.crd.york.ac.uk/prospero/; Unique identifier: CRD42021272756]).
Results
Based on 482 316 person-years of follow-up, we identified 22 035 deaths, including 9110 deaths from cardiovascular disease (CVD). Greater dietary cholesterol and egg consumption were associated with increased risk of overall and CVD-related mortality. Hazard ratios for each additional 300 mg cholesterol intake per day were 1.10 and 1.13 for overall and CVD-related mortality, respectively; for each additional 50-g egg consumed daily, hazard ratios were 1.06 and 1.09, respectively, for overall and CVD-related mortality (all P valuesP2=80.1%). In the subgroup analysis of geographic regions (Pinteraction=0.02), an increase of 50-g egg consumed daily was associated with a higher risk of CVD in US cohorts (pooled relative risk, 1.08 [95% CI, 1.02-1.14]) and appeared related to a higher CVD risk in European cohorts with borderline significance (pooled relative risk, 1.05), but was not associated with CVD risk in Asian cohorts.
Conclusions
In this prospective cohort study and updated meta-analysis, greater dietary cholesterol and egg consumption were associated with increased risk of overall and CVD-related mortality. Our findings support restricted consumption of dietary cholesterol as a means to improve long-term health and longevity.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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